We know gout is among the many comorbidities that increase the risk of cardiovascular disease (CVD). In 2018, the cardiovascular safety of febuxostat and allopurinol in patients with gout and cardiovascular morbidities (CARES) trial concluded that febuxostat was non-inferior to allopurinol. BUT, two of the secondary endpoints were very concerning. Febuxostat was inferior to allopurinol in terms of cardiovascular death and all-cause mortality. Many clinicians were left wondering whether febuxostat was cardiotoxic …. or conversely, perhaps allopurinol was cardioprotective. Will another cardiovascular outcome trial provide greater clarity to guide clinical practice?
Guest Authors: Sophia Dietrich, PharmD and Michael W. Nagy, PharmD, BCACP
Guest Panelist: Dawn Fuke, PharmD, BCPS
Music by Good Talk
Sequential Additions or Multicomponent Combination? Should Our Approach to Hypertension Be Re-examined?
Extra Protection? Finerenone Use in Patients with Type 2 DM and CKD
Assessing HER Acceptability of Contraception
Preserving hope for patients with Heart Failure with Preserved Ejection Fraction (HFpEF)?
Top Ten Things Every Clinician Should Know about Continuous Glucose Monitors (CGM)
Spice Up Your Sleep Life with Saffron
Will a Dual GIP/GLP-1 Receptor Agonist SURPASS the Crowd?
Cut It Out! Removing EHR Allergy Warnings to Improve Antimicrobial Stewardship
What’s the Right Dose of Aspirin in Patients with Heart Disease?
Bursting the Steroid Bubble: Short-term Use Has Its Consequences
Guiding Antiplatelet Therapy: Is a Personalized Approach Worth It?
Psilocybin for Depression: Is it Worth the Trip?
Up the Creek Without a Paddle? Look to Your Pharmacist to Bridge-It
SGLT2i plus MRAs for Heart Failure: A Sweet or Sour Combination?
Is As-Needed Nasal Corticosteroid Use Needed for Allergic Rhinitis Management?
STEP-ping Up the Game for Weight Management
Raised From The Grave: A Second Life for Sotagliflozin?
Tiny (n-of-1) Trials to Overcome Statin-Associated Muscle Pain
Top Ten Things Every Clinician Should Know About Infographics
Mind Over Migraine: Can Mindfulness Improve Outcomes?
Create your
podcast in
minutes
It is Free
Good Nurse Bad Nurse
On Call With Dr. Anselm Anyoha
Precision Medicine Forum Podcast
The Peter Attia Drive
THE MCCULLOUGH REPORT