A Systematic Review of the Biological Mediators of Fat Taste and Smell

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Dr. Paule V. Joseph about her article “A Systematic Review of the Biological Mediators of Fat Taste and Smell,” the first systematic review to be published in Physiological Reviews.

Dr. Joseph is Lasker Clinical Research Scholar, Tenure Track Clinical Investigator, and Chief of the Section of Sensory Science and Metabolism in the Division of Intramural Clinical and Biological Research at the National Institute of Alcohol Abuse and Alcoholism. She has a a joint appointment at the National Institute of Nursing Research. Dr. Joseph’s research focuses on preclinical, clinical, and translational studies of chemosensory disorders. In August 2022, she was selected as the inaugural 2022–2024 American Academy of Nursing Fellow at the National Academy of Medicine. Dr. Joseph is a member of the Physiological Reviews Editorial Board.

• Introduction of Dr. Joseph [1:07]
• Author’s background [2:40]
• Why did Dr. Joseph and her coauthors write a systematic review instead of a narrative review? [6:47]
• Discussion of the main receptors responsible for the sensations of taste and smell, and how their activation relates to obesity [10:12]
• How does SARS-CoV-2 result in loss of taste and smell, and why does it occur following a COVID infection and not with other respiratory viruses? [14:40]
• Are polymorphisms associated with obesity or, conversely, with very low body mass index (BMI)? [19:49]
• Do environmental factors play a role in the regulation of fat and smell receptors? [22:39]
• Suggestions for improving outreach within the nursing community [25:26]

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