09 - Instant insights: Kidney Profile and eGFR with Creatinine and Cystatin-C (7 min)

1in 7 US adults are estimated to have chronic kidney disease, or CKD. Because early stages of the disease are often clinically silent, 90% of individuals with CKD don’t know they have it. This podcast highlights the importance of early CKD detection and the need for proper screening, especially in individuals with hypertension and diabetes. The Kidney Profile aligns with guidelines and includes the urine-albumin-creatinine ratio and eGFR. The new 2024 guidelines recommend using both creatinine and Cystatin C in estimating eGFR in certain populations, which provides a more accurate risk assessment for CKD and other cardiometabolic conditions like heart disease and stroke. By adopting this dual approach, healthcare providers can improve early detection, staging, and management of CKD, leading to better patient outcomes.

This episode will

• Explore the role of the Kidney Profile in CKD diagnosis and how it aligns with the 2024 KDIGO guidelines. (1:40, 5:15)
• Identify at-risk populations for CKD, including those with hypertension and diabetes, and understand the importance of early screening and management. (1:30)
• Investigate how combining creatinine and cystatin C in eGFR improves the prediction of CKD progression and associated cardiometabolic risks. (4:30)

The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions.

Date: 12/2024

Speaker(s): Maeson Latsko, PhD

Contributor(s): Maeson Latsko, PhD; Trisha Winchester, PhD

Additional Resources:

Quest Diagnostics Clinical Education Center [Link]

Ordering information:

 Kidney Profile [link]

Kidney Profile Test Summary [link]

eGFR with Creatinine and Cystatin C [link]

References:

 

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314. doi:10.1016/j.kint.2023.10.018

National Kidney Foundation. Kidney Disease: Fact Sheet. National Kidney Foundation. August 6, 2024. Accessed December 19, 2024. https://www.kidney.org/about/kidney-disease-fact-sheet