In this episode of the Let’s Go Win Podcast, JM sits down with Dr. Nathan Bryan, one of the world’s leading experts on nitric oxide, to unpack why this tiny gas molecule may be the most overlooked driver of long term health, performance, and aging. Discovered as a signaling molecule only a few decades ago and recognized with a Nobel Prize, nitric oxide quietly regulates blood flow, inflammation, mitochondrial function, and immune balance. Dr. Bryan explains why the loss of nitric oxide production is ...
In this episode of the Let’s Go Win Podcast, JM sits down with Dr. Nathan Bryan, one of the world’s leading experts on nitric oxide, to unpack why this tiny gas molecule may be the most overlooked driver of long term health, performance, and aging. Discovered as a signaling molecule only a few decades ago and recognized with a Nobel Prize, nitric oxide quietly regulates blood flow, inflammation, mitochondrial function, and immune balance. Dr. Bryan explains why the loss of nitric oxide production is now considered the earliest event in many chronic diseases, including heart disease, diabetes, neurodegeneration, autoimmune conditions, and poor wound healing. Together, they explore what destroys nitric oxide in modern life, what daily habits restore it, and how small changes in breathing, diet, oral care, movement, and sleep can create outsized improvements in energy, cognition, vascular health, and recovery.
Key takeaways:
- Why nitric oxide is a root level regulator of cardiovascular, metabolic, immune, and mitochondrial health
- How reduced nitric oxide production is linked to nearly every age related chronic disease
The surprising role of the oral microbiome in nitric oxide production and systemic health
- Why antiseptic mouthwash, excess sugar, fluoride exposure, and chronic antacid use can sabotage nitric oxide pathways
- How nasal breathing directly increases nitric oxide and improves oxygen delivery
- The impact of intermittent fasting and blood sugar control on vascular and mitochondrial function
- Which daily habits reliably stimulate nitric oxide production through natural mechanisms
- What to know about beet products, supplements, and nitric oxide delivery methods that actually work
- How restoring nitric oxide can translate into better blood pressure, energy, sleep, healing, and cognitive clarity
- Why lifestyle based nitric oxide support may outperform many pharmaceutical approaches for prevention and longevity
This episode is for anyone who cares about aging well, preventing chronic disease, improving performance, or taking ownership of their health beyond symptom chasing. If you are a high performer dealing with fatigue, inflammation, poor recovery, brain fog, blood pressure issues, or metabolic challenges, this conversation will give you a new lens on what might be missing. You will walk away with a practical checklist you can apply immediately, a deeper understanding of how your daily habits either block or support your body’s natural healing systems, and a science backed framework for improving health from the ground up. This is not about biohacking trends. It is about restoring a fundamental biological signal your body depends on to thrive.
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