Vaccines are formidable tools against infectious disease. But the success of a vaccine in one part of the world doesn’t guarantee similar outcomes elsewhere. That’s where human infection studies come in – where volunteers, closely monitored by researchers, receive a vaccine and are subsequently given a small dose of an infectious disease. This might sound worrying, but it is a quick and effective way to get data about whether a vaccine is working.
Alisha speaks with Dr Dingase Dula, who researched a pneumococcal vaccine in Malawi, to learn more about the impact of infection studies. They also meet Becky Mkandawire and Stonard Mwale, who volunteered to take part in the study. They discuss the role of trust in human infection studies, what it’s like to be part of one, and the importance of African-led research in combating infectious disease.
When Science Finds a Way is brought to you by Wellcome, an independent global foundation that supports science to solve the urgent health challenges facing everyone. For more information visit www.wellcome.org/news-and-reports/podcast.
Bonus Episode: What does the future hold for global health?
Will genomic sequencing prevent future pandemics?
Should we give out cash to improve mental health?
How can we feed the world with a changing climate?
Waking up: How can sleep impact on mental health?
One scientist’s journey to respecting indigenous customs
One billion homes: How can we revitalize informal settlements?
Can new technology help predict psychosis?
Can a research study change a city?
How can we work on a heating planet?
How is research helping the fight for equality?
What can we do to stop superbugs?
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