Today marks the reboot of our journal club series, so you can look forward to seeing these episodes as part of our regular feed.
This episode is a scientific deep dive on recent research published by Ben Cravatt, Professor in the Department of Chemistry at the Scripps Research Institute and co-founder of a diverse suite of chemoproteomic companies such as Vividion and Belharra Therapeutics, and Gene Yeo, Professor of Cellular and Molecular Medicine at the University of California, San Diego and co-founder of Locana Bio, Eclipse Bio, and Trotana Therapeutics.
Ben and Gene are joined by Vineeta Agarwala, general partner at a16z Bio + Health, and bio deal team member Bryan Faust.
Together, they’ll discuss some unexpected mechanistic results of finding covalent binders to a class of proteins that we are just starting to understand — RNA binding proteins — and the subsequent translational implications that they described in a recent paper published by the Cravatt and Yeo labs in Nature Chemical Biology. The paper outlines a potentially new therapeutic approach that uses small molecules to fundamentally rewire transcriptional networks in cancer cells.
Additional reading:
The Science and Supply of GLP-1s with Brooke Boyarsky Pratt
The Science and Supply of GLP-1s with Carolyn Jasik
The Intersection of Biotech x High Tech with Vineeta Agarwala
AI in Pharmaceutical R&D with Kim Branson
Unleashing CAR T with Carl June
Longevity as a Health Asset with Tom Hale
The Power of Drug Discovery with Philip Tagari
AI-Enabled Continuity of Care with Ed and Todd Park
Grand Challenges in Healthcare AI with Vijay Pande and Julie Yoo
Adapting Biopharma to AI with Greg Meyers
Behind the Buy: Payors and Providers on AI Adoption
Biotech Revolution with Software Engineering Daily
Dark Genome Hunting with Rosana Kapeller and Marty Taylor
DNA as Data Storage with Vijay Pande
The Most Interesting Healthcare Companies You've Never Heard Of with Julie Klapstein
CRISPR by Design with Benjamin Oakes
Metrics for a Complex Machine with Josh Clemente
Transitioning From Gymnast to Investor with Aly Raisman
Finding PMF in Healthcare (After Tasting it Elsewhere) with Eren Bali and Max Cohen
IRA, AI Regulation, and the Future with Joe Grogan
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