In this episode of the Making Sense podcast, Sam Harris speaks with Roland Griffiths about the current state of research on psychedelics. They discuss the historical prohibition against their use; the clinical and scientific promise of psilocybin, mescaline, LSD, DMT, MDMA, and other compounds; the risks associated with these drugs; the roll of “set and setting”; the differences between psychedelics and drugs of abuse; MDMA and neurotoxicity; experiences of unity, sacredness, love, and truth; the long-term consequences of psychedelic experiences; synthetic vs natural drugs; the prospects of devising new psychedelics; microdosing; research on psilocybin and long-term meditators; the experience of encountering other apparent beings; psilocybin treatment of addiction; and other topics. In his Afterword, Sam discusses his experience on a large dose of psilocybin—his first psychedelic experience in 25 years.
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#366 — Urban Warfare 2.0
#365 — Reality Check
#364 — Facts & Values
#363 — Knowledge Work
#362 — Six Months of War
#361 — Sam Bankman-Fried & Effective Altruism
#360 — We Really Don’t Have Free Will?
#359 — Getting Used to It
#358 — The War in Ukraine
#357 — America & World Order
#356 — Islam & Freedom
#355 — A Falling World
#354 — Is Moral Progress a Fantasy?
#353 — Race & Reason
#352 — Hubris & Chaos
#351 — 5 Myths about Israel and the War in Gaza
#350 — Sharing Reality
#349 — Generosity, Cynicism, and the Future of Doing Good
#348 — The Politics of Antisemitism
#347 — Finding Sanity in 2024
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