The Astounding Account of the IL-17 and Spondylarthritis

2025-07-28

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In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA · Intro 0:01 · In this episode 0:12 · Leonard Calabrese, DO, is listening! 0:54 · Recap of last episode 3:09 · Putting the pieces together 5:12 · Quick overview of this science heavy episode 6:11 · ...

In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA

· Intro 0:01

· In this episode 0:12

· Leonard Calabrese, DO, is listening! 0:54

· Recap of last episode 3:09

· Putting the pieces together 5:12

· Quick overview of this science heavy episode 6:11

· What is psoriasis? 7:26

· Immunosuppressants for psoriasis/ Throwing meds at people and seeing what happens 10:10

· In the modern world of 1986 – olive oil placebo trial 11:36

· A quick aside into fungi 12:35

· What kind of T-cells are involved here? 16:41

· The TH-1 hypothesis 18:20

· IL-23 and IL-17 are doing something 19:34

· Going back to the drawing board in 2004 20:00

· p40 + p19 = IL-23 21:00

· IL-23 via minicircle DNA in mice 23:05

· Brand new and shiny TH-17 25:23

· The family of IL-17 26:36

· What do we know about IL-17 and psoriasis? 27:10

· IL-17A vs IL-17F in mouse studies 27:35

· Finding the difference between IL-17A and IL-17F in humans 28:23

· What exactly is IL-17 doing? 29:30

· The articular manifestations of psoriatic arthritis 30:57

· Spondylarthritis and the IL 23/17 axis 33:56

· T-cells we haven’t talked about 35:40

· Summary of this episode 39:08

· Thanks for listening 41:34

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

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Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta

Bjerke R J. Acta Derm Venereol. 1982;PMID:6179355

Cargill M, et al. Am J Hum Genet. 2007;doi:10.1086/511051

Chan J R, et al. J Exp Med. 2006;doi:10.1084/jem.20060244

Cuthbert R J, et al. Ann Rheum Dis. 2019;doi:10.1136/annrheumdis-2019-215210

Ellis C N, et al. JAMA. 1986;doi:10.1001/jama.1986

Ettehadi P, et al. Clin Exp Immunol. 1994;doi:10.1111/j.1365-2249.1994.tb06244.x

Furue M, et al. Int J Mol Sci. 2020;doi:10.3390/ijms21041275

Gooderham M J, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868

Lee E, et al. J Exp Med. 2004;doi:10.1084/jem.20030451

Leonardi C L, et al. Lancet. 2008;doi:10.1016/S0140-6736(08)60725-4