The History, Challenges, and Future Development of Pediatric Pneumococcal Conjugate Vaccines

Drs Todd A. Florin and Richard Malley discuss the history, challenges, and future directions of pneumococcal vaccination, including expanding serotype coverage and methods of worldwide distribution.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987060). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Pediatric Pneumonia https://emedicine.medscape.com/article/967822-overview

Masking the Pathogen: Evolutionary Strategies of Fungi and Their Bacterial Counterparts https://pubmed.ncbi.nlm.nih.gov/29376918/

Priming and Induction of Haemophilus Influenzae Type B Capsular Antibodies in Early Infancy by Dpo20, an Oligosaccharide-protein Conjugate Vaccine https://pubmed.ncbi.nlm.nih.gov/3499499/

About Pneumococcal Vaccines https://www.cdc.gov/vaccines/vpd/pneumo/hcp/about-vaccine.html

Haemophilus Influenzae Type B Vaccine (Rx) https://reference.medscape.com/drug/acthib-hiberix-haemophilus-influenzae-type-b-conjugate-vaccine-343149

Haemophilus Influenzae https://www.ncbi.nlm.nih.gov/books/NBK562176/

Efficacy, Safety and Immunogenicity of Heptavalent Pneumococcal Conjugate Vaccine in Children. Northern California Kaiser Permanente Vaccine Study Center Group https://pubmed.ncbi.nlm.nih.gov/10749457/

Streptococcus Pneumoniae Serotype 19A: Worldwide Epidemiology https://pubmed.ncbi.nlm.nih.gov/28783380/

Pneumococcal Vaccine 13-valent (Rx) https://reference.medscape.com/drug/prevnar-13-pneumococcal-vaccine-13-valent-999483

Pneumococcal Polysaccharide Protein D-conjugate Vaccine (Synflorix; PHiD-CV) https://pubmed.ncbi.nlm.nih.gov/19725600/

Pneumococcal Vaccine 15-valent (Rx) https://reference.medscape.com/drug/vaxneuvance-pneumococcal-vaccine-15-valent-4000165

Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection https://pubmed.ncbi.nlm.nih.gov/32192117/

Meningococcal Group B Vaccine (Rx) https://reference.medscape.com/drug/trumenba-bexsero-meningococcal-group-B-vaccine-999974

Serotype Replacement After Introduction of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe https://pubmed.ncbi.nlm.nih.gov/34932457/

Sugar-coated Killer: Serotype 3 Pneumococcal Disease https://pubmed.ncbi.nlm.nih.gov/33425786/

Prevalence of Nasopharyngeal Pneumococcal Colonization in Children and Antimicrobial Susceptibility Profiles of Carriage Isolates https://pubmed.ncbi.nlm.nih.gov/26327122/

Community-acquired Pneumonia https://www.ncbi.nlm.nih.gov/books/NBK430749/