Question: Would you use bisphosphonate drugs to treat spaceflight related bone loss for long duration space missions?
Follow us on twitter! https://twitter.com/TalkSpaceMed
Join our discord! https://www.google.com/url?q=https%3A%2F%2Fdiscord.gg%2FWtUcKYyH3b&sa=D&sntz=1&usg=AFQjCNFWSYEMvPusokT0AL50JKsRt2cg8g
Credit: Everyday Astronaut for intro music! (Listen here) https://www.youtube.com/watch?v=LQMq4YEMvH8&list=PL-ptSDHlAdQNZ4LxFv_c5MEsmQ6i8bQUN&pbjreload=101&ab_channel=EverydayAstronaut (Buy here) https://www.amazon.com/Maximum-Aerodynamic-Pressure-Everyday-Astronaut/dp/B07KPVRG67/ref=sr_1_1?dchild=1&keywords=maximum+aerodynamic+pressure&qid=1612331710&sr=8-1
References
1. Watts NB, Bilezikian JP, Camacho PM, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract. 2010;16(Suppl 3):1-37. doi:10.4158/EP.16.S3.1
2. Sibonga JD. Spaceflight-induced bone loss: Is there an Osteoporosis Risk? Curr Osteoporos Rep. 2013;11(2):92-98. doi:10.1007/s11914-013-0136-5
3. Kennel KA, Drake MT. Adverse Effects of Bisphosphonates: Implications for Osteoporosis Management. Mayo Clin Proc. 2009;84(7):632-638. doi:10.1016/s0025-6196(11)60752-0
4. Program HR. Human Research Program Integrated Research Plan.; 2020.
5. Sibonga JD, Spector ER, Johnston SL, Tarver WJ, Reeves JM. Evaluating bone loss in ISS astronauts. Aerosp Med Hum Perform. 2015;86(12 Suppl):A38-A44. doi:10.3357/AMHP.EC06.2015
6. Blaber EA, Dvorochkin N, Lee C, et al. Microgravity Induces Pelvic Bone Loss through Osteoclastic Activity, Osteocytic Osteolysis, and Osteoblastic Cell Cycle Inhibition by CDKN1a/p21. PLoS One. 2013;8(4). doi:10.1371/journal.pone.0061372
7. Blaber EA, Dvorochkin N, Torres ML, et al. Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration. Stem Cell Res. 2014;13(2):181-201. doi:10.1016/j.scr.2014.05.005
8. McCarthy I, Goodship A, Herzog R, Oganov V, Stussi E, Vahlensieck M. Investigation of bone changes in microgravity during long and short duration space flight: Comparison of techniques. Eur J Clin Invest. 2000;30(12):1044-1054. doi:10.1046/j.1365-2362.2000.00719.x
9. Leblanc A, Schneider V, Shackelford L, et al. Bone Mineral and Lean Tissue Loss after Long Duration Space Flight. Vol 1.; 2000.
10. Collet P, Uebelhart D, Vico L, et al. Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans. Bone. 1997;20(6):547-551. doi:10.1016/S8756-3282(97)00052-5
11. Coulombe JC, Senwar B, Ferguson VL. Spaceflight-Induced Bone Tissue Changes that Affect Bone Quality and Increase Fracture Risk. Curr Osteoporos Rep. 2020;18(1). doi:10.1007/s11914-019-00540-y
12. LeBlanc A, Matsumoto T, Jones J, et al. Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight. Osteoporos Int. 2013;24(7):2105-2114. doi:10.1007/s00198-012-2243-z
13. Mashiba T, Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB. Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res. 2000;15(4):613-620. doi:10.1359/jbmr.2000.15.4.613
14. Ammann P, Rizzoli R. Bone strength and its determinants. Osteoporos Int. 2003;14 Suppl 3. doi:10.1007/s00198-002-1345-4
AsMA 2023 Pre-Meeting Podcast
Orbit 12 - Space is Rad!
Orbit 11 - SANS : Your Brain on Space!
Orbit 10 - Genetic Enhancements : Is that the Question?
Orbit 9 - Fracture Risk : Go Break a Leg!
Orbit 8 - Space Surgery : Before, During, After, or Not at All?
Orbit 7 - Ranking Red Risks!
Episode 6 - Space Vision : Orbit Changes In Orbit!
Orbit 6 - Space Nutrition : NASA-eats is now delivering!
Orbit 5 - Yuri's Night/Crew-2 Celebration!
Orbit 4 - Musculoskeletal Health : Muscle Vs Bone
Orbit 3 - Astronaut Selection : Making Space For Everyone
Episode 5 - Space Radiation : Engineering Solutions vs Precision Medicine
Orbit 2 - Space Radiation : Don't Forget the Sunscreen
Episode 4 - Space Motion Sickness, Cephalic Fluid Shifts, & Re-Acclimation : Simply Head Spinning!
Orbit 1 - Gravity Re-Adaptation : Starting Off on the Right Foot
Orbit 0 - Launch! : Intro to Long Form Podcast
Episode 3 - The CO2 Problem: What a Headache!
Episode 2 - Contraceptive Pill & Bone Health: Two Birds with One Stone?
Create your
podcast in
minutes
It is Free
Good Mood Revolution
Good Nurse Bad Nurse
The Relaxback UK Show
On Call With Dr. Anselm Anyoha
The Peter Attia Drive
The Doctor’s Farmacy with Mark Hyman, M.D.