Esketamine for depression, registered reports, and alcohol use disorder | Metascience Matters #2

Florian Naudet is a Professor of Therapeutics at Rennes University. As a metascientist and psychiatrist, his research interests lie in developing and evaluating methodological solutions to treatment assessment, primarily but not exclusively for mental health conditions. His work has also made inroads to quantifying and understanding research waste and the prevalence of substandard data-sharing practices.

CONTACT RANDY:

Feedback: metasciencematters@gmail.com

EPISODE LINKS:

Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials

https://link.springer.com/article/10....

Vibration of effects from diverse inclusion/exclusion criteria and analytical choices: 9216 different ways to perform an indirect comparison meta-analysis

https://link.springer.com/article/10....

Pharmageddon (book)

https://davidhealy.org/pharmageddon-i...

A manifesto for reproducible science

https://www.nature.com/articles/s4156...

Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trial

https://pmc.ncbi.nlm.nih.gov/articles...

OUTLINE:

0:00 - Introduction

0:36 - Florian's origin story as a psychiatrist and metascientist

4:46 - How Florian became interested in metascience

11:55 - Systematic review of clinical trials of Esketamine for depression

28:45 - Publishing this study as a registered report

40:49 - Vibration-of-effects analysis of double-blind randomized controlled trials assessing nalmefene and/or naltrexone for treating alcohol use disorders

59:58 - Advice for listeners interested in pursuing research like Florian's

1:03:38 - Outro