In this episode:
The first draft of the human genome ushered in a new era of genetics research. Since its publication, researchers have constructed ever more accurate ‘reference genomes’ – baselines against which others are compared. But these are based on the DNA of a small number of people, and don’t represent the genetic variation known to exist across human populations. To address this, a consortium of researchers have published the first draft of a ‘pangenome’, which combines the genomes of 47 genetically diverse individuals. This draft provides a more complete picture of the human genome, and is the starting point for a project that aims to include sequences from 350 individuals.
Research article: Liao et al.
Research article: Vollger et al.
Research article: Guarracino et al.
News and Views Forum: Human pangenome supports analysis of complex genomic regions
A wearable sensor that lets users see infrared light, and how a vulture’s culture can influence its dining habits.
Research Highlight: Wearable sensor gives a glimpse of ‘invisible’ light
Research Highlight: What drives a scavenger’s diet? Vulture culture
We discuss some highlights from the Nature Briefing. This time, a new phosphate-storing organelle found in fruit fly cells, and how extracted DNA revealed who held a deer-tooth pendant 20,000 years ago.
Nature News: New cellular ‘organelle’ discovered inside fruit-fly intestines
Nature News: Prehistoric pendant’s DNA reveals the person who held it
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Alphafold 3.0: the AI protein predictor gets an upgrade
Talking about sex and gender doesn't need to be toxic
Dad's microbiome can affect offsprings' health — in mice
Audio long read: Why loneliness is bad for your health
How gliding marsupials got their 'wings'
Living on Mars would probably suck — here's why
Keys, wallet, phone: the neuroscience behind working memory
The 'ghost roads' driving tropical deforestation
Audio long read: Why are so many young people getting cancer? What the data say
Pregnancy's effect on 'biological' age, polite birds, and the carbon cost of home-grown veg
How climate change is affecting global timekeeping
AI hears hidden X factor in zebra finch love songs
Killer whales have menopause. Now scientists think they know why
These tiny fish combine electric pulses to probe the environment
Could this one-time ‘epigenetic’ treatment control cholesterol?
Audio long read: Chimpanzees are dying from our colds — these scientists are trying to save them
How whales sing without drowning, an anatomical mystery solved
Why are we nice? Altruism's origins are put to the test
Smoking changes your immune system, even years after quitting
Why we need to rethink how we talk about cancer
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