110: Evaluating Aquablation Therapy to Treat Prostate Cancer – WATER IV Prostate Cancer Trial – Inderbir S. Gill, MD

2025-12-23

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There is now a significant opportunity to improve the safety and quality of life outcomes for men requiring treatment for prostate cancer. Today, we're discussing the Water IV Prostate Cancer trial, an innovative and meaningful clinical trial that is actively enrolling patients to assess how the safety and efficacy of Aquablation therapy compares with radical prostatectomy in men with localized prostate cancer. I'm excited to share my experience as a current investigator for that study and to have Dr. Inderbir Gill, the co-principal investigator from the University of Southern California, join us. Dr. Gill is the current Chairman and Distinguished Professor of Urology of the University of Southern California Department of Urology. He is also the Founding Executive Director of the USC Institute of Urology. Stay tuned to learn who qualifies as a candidate to participate in the trial, how the study works, and how you can get involved.

There is now a significant opportunity to improve the safety and quality of life outcomes for men requiring treatment for prostate cancer.

Today, we're discussing the Water IV Prostate Cancer trial, an innovative and meaningful clinical trial that is actively enrolling patients to assess how the safety and efficacy of Aquablation therapy compares with radical prostatectomy in men with localized prostate cancer. I'm excited to share my experience as a current investigator for that study and to have Dr. Inderbir Gill, the co-principal investigator from the University of Southern California, join us.

Dr. Gill is the current Chairman and Distinguished Professor of Urology of the University of Southern California Department of Urology. He is also the Founding Executive Director of the USC Institute of Urology.

Stay tuned to learn who qualifies as a candidate to participate in the trial, how the study works, and how you can get involved.

Disclaimer: The Prostate Health Podcast is for informational purposes only. Nothing in this podcast should be construed as medical advice. By listening to the podcast, no physician-patient relationship has been formed. For more information and counseling, you must contact your personal physician or urologist with questions about your unique situation.

Pertinent disclosure for today's episode – Today's episode is sponsored by PROCEPT BioRobotics Corporation, which manufactures and sells the Aquablation system. Dr. Pohlman is also a paid advisor for PROCEPT BioRobotics Corporation.

Show Highlights:

How the Water IV Prostate Cancer trial compares Aquablation directly with radical prostatectomy
How the Water IV Prostate Cancer trial is the first prospective, randomized U.S. trial comparing a novel prostate cancer treatment to radical prostatectomy.
Who qualifies as an eligible participant for the Water IV Prostate Cancer trial?
The requirements for those participating in the Water IV Prostate Cancer trial
How the trial randomizes the participants in the trial
What the study measures as its primary and secondary endpoints
How recruitment for the trial has exceeded all expectations
When the early trial results should come out

Links:

WATER IV Prostate Cancer Study webpage: water4pca.com

Contact the study team: wateriv@procept-biorobotics.com

Aquablation Therapy website: https://aquablation.com/

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