Lessons in Longevity: The Science Behind OneSkin with Co-Founders Carolina Reis Oliveira and Alessandra Zonari

In this episode of Skin Anarchy, Dr. Ekta Yadav welcomes Carolina Reis Oliveira and Alessandra Zonari, co-founders of OneSkin, for a rigorous, eye-opening conversation that reframes skincare as a true longevity intervention. Part of the Lessons in Longevity series, this episode asks a bold question: what if skin aging isn’t cosmetic at all—but cellular, systemic, and deeply biological?

OneSkin began not as a brand, but as a lab-based mission. Trained in stem cell biology, tissue engineering, and genomics, Carolina and Alessandra spent years growing real human skin in the lab to test existing products. What they found challenged the industry: many so-called “anti-aging” formulas increased inflammation, cellular stress, and long-term damage. Meanwhile, longevity science was accelerating—yet skin, the body’s largest organ, was being left out of the conversation.

At the center of the episode is cellular senescence—a state where damaged cells stop dividing and begin secreting inflammatory signals that degrade surrounding tissue. In skin, this process weakens the barrier, disrupts collagen, and accelerates visible aging. Rather than masking symptoms, OneSkin set out to target this root cause. After screening hundreds of compounds, they developed OS-01, a proprietary peptide shown in lab models to significantly reduce senescent cell burden while increasing collagen—without irritation.

The conversation also expands beyond the face. OneSkin’s decision to focus on body skin revealed something unexpected: improving the skin barrier may reduce systemic inflammation. Clinical data discussed in the episode suggests that healthier skin doesn’t just look better—it may influence whole-body aging.

This episode is a must-listen for anyone curious about where skincare, biotech, and longevity science truly intersect.

Listen to the full episode of Skin Anarchy to hear how OneSkin is redefining skin as a living organ—and why the future of longevity may start at the surface.

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