How to Lose Weight and Fix Your Metabolism in 2026 | Dr Mauricio Gonzalez

2026-06-22

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For decades we have treated the number on the scale as the goal of metabolic health. Dr Mauricio Gonzalez, a triple board-certified physician and endocrinology fellow practising in New York, makes the case that we have been measuring the wrong thing. In this conversation we explore why liver fat, not body weight, is becoming the real target, what the latest weight-loss medications can and cannot do, and how to cut through the hype and dogma that surround this field. What we cover: Why isolated blood tests and blood...

In this conversation we explore why liver fat, not body weight, is becoming the real target, what the latest weight-loss medications can and cannot do, and how to cut through the hype and dogma that surround this field.

What we cover:

Why isolated blood tests and blood pressure readings tell you very little
The myth that GLP-1 medications are "the easy way out"
Why liver fat may matter more than body weight
How diabetes clinics now remove medications instead of adding them
Which supplements earn their place, and which Mauricio has cooled on
The minimum effective dose for exercise, and knowing when "enough" is enough

A grounded, practical conversation with a doctor who meets people where they are. If you enjoy the show, please take a moment to rate and review The Proof on Apple Podcasts or Spotify, it genuinely helps more people find these conversations.

To connect with Dr Mauricio Gonzalez, follow him on Instagram, X, and YouTube, or visit his website at drmauriciogonzalez.com.

Intro (00:00)
Minimum Effective Dose for Exercise (01:38)
Why Continuity of Care Reduces Mortality (07:09)
How Type 2 Diabetes Silently Develops Over 12 Years (09:23)
Statin vs. PCSK9 Inhibitor: How Doctors Choose (12:45)
How GLP-1 Drugs Transformed the Diabetes Clinic (21:46)
Why Doctors Now Measure Organ Fat, Not Body Weight (30:25)
How Fatty Liver Disease Is Diagnosed (34:05)
How Liver Fat Drives Insulin Resistance (40:47)
Wegovy vs. Zepbound: How to Choose a GLP-1 (48:18)
Should Lean People Use GLP-1s for Metabolic Health? (51:53)
Why Patients Feel Guilty Taking GLP-1s (54:13)
How Mauricio’s Nutrition Advice Has Evolved Over a Decade (01:04:35)
Supplements on GLP-1s: What's Worth Taking (01:09:42)
Minimum Effective Dose for Resistance Training (01:16:52)
When Health Optimization Becomes Counterproductive (01:21:20)

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Simon Hill, MSc, BSc (Hons)