Joe Lonsdale: American Optimist
Technology
Every year, more than 20,000 Americans receive a bone marrow transplant — a Nobel prize-winning procedure that saves many lives but also carries great risk. For leukemia patients, it's a choice of last resort, as nearly 20% die from the transplant. Ivan Dimov, co-founder & CEO of Orca Bio, and his team have created a novel cell therapy alternative that has already saved over 400 lives in clinical trials with virtually zero rejection!This week, we dive into Ivan's journey, the science behind Orca's cancer breakthrough, and the potential of cell therapies to cure a host of other diseases. By discovering new, high-precision methods to manipulate cells, Orca is able to provide leukemia patients with a designer immune system that attacks the cancer while nearly eliminating rejection. By safely rebooting the immune system, Ivan and his team believe Orca also has the potential to cure autoimmune diseases like Crohn’s disease and multiple sclerosis, and impact the lives of millions of Americans.Orca is currently seeking the first-ever FDA approval in this space, and since it's a unique one-time curative therapy, they are also commercializing the drug in-house — a rare move in biopharma. Ivan walks us through the path to bringing Orca's products to market, from collaborating with regulators to negotiating with insurance companies and scaling up its manufacturing. Though many challenges remain, you'll see why we're incredibly bullish on Ivan's leadership and Orca's potential to transform the future of medicine.
Ep 90: Ethan Penner on Choosing Greatness & Pioneering New Markets on Wall Street
Ep 89: Coleman Hughes on "The End of Race Politics" & the Worst Ideas Done in the Name of Diversity
Ep 88: A Conversation with MLK's Attorney & Speechwriter: Dr. Clarence Jones
Ep 87: Dr. Cliff Winston — Deregulate Lawyers, Deregulate Airlines, and Let Markets Correct Themselves
Ep 86: How to Design a STEM Curriculum for the 21st Century with Dr. David Ruth
Ep 85: The Path to Regime Change in Iran with Crown Prince Reza Pahlavi
Ep 84: Sri Ganesan on Freshworks' Big Win, Building Rocketlane & India's Tech Boom
Ep 82: Whitney Baker's Masterclass on Macro Investing & the State of the Economy
Ep 81: How Palantir Star Tyler Scriven Is Helping Small Businesses Compete Against Amazon
Ep 80: Leonard Leo's Winning Strategy to Rebuild Institutions, Accelerate Innovation, and Save Our Country
Ep 79: Bjorn Lomborg and the 12 Best Policies to Help the World
Ep 78: Emil Michael — the Master Dealmaker Behind Uber's Global Dominance
Ep 77: Mike Solana on Exposing Government Corruption, Saving San Francisco, and Building a New Media Empire
Ep 76: Accelerate or Die! Guillaume Verdon and the e/acc Movement
Ep 75: Leadership Lessons with Intuit Founder & Silicon Valley Legend Scott Cook
Ep 74: A Turning Point in Higher Education with Pano Kanelos & Niall Ferguson
Ep 73: How Candid Health Is Fixing the $280B Healthcare Billing Fiasco, With Lessons from Palantir
Ep 72: Illegal Chinese Bio Labs & Secret Police in the U.S.; Investigating the CCP with Congressman Mike Gallagher
Ep 71: Reinventing Community College with Tade Oyerinde, Chancellor of Campus
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