Ep 46-Don’t Die: Bryan Johnson and Longevity Science

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A cookie-fueled cold open gives way to one of the thorniest questions in modern medicine: are we getting healthier, or just better at making numbers look good? Using Brian Johnson’s “Blueprint” as a case study, we unpack the science behind epigenetic clocks, the appeal of tight control, and the lesson medicine keeps relearning—lowering a risky marker isn’t the same as improving a life. We trace hard-won examples from ICU glucose control to HRT and anti-arrhythmics, then map that history onto today’s longevity culture, where proxies move fast and outcomes arrive slow.

Enjoy the ride, laugh at the holiday detours, and leave with a pragmatic checklist: sleep on purpose, move daily, eat simply, and be skeptical when a perfect metric is sold as a cure. If this resonated, follow the show, share it with a friend, and leave a quick review—your support helps us keep the conversation honest and useful.

Resources: 

• Steve Horvath’s original epigenetic clock (2013, Genome Biology)
• National Law Review+1
• BryanJohnson.com
• GrimAge and PhenoAge models (Aging, Nature Communications)
• DunedinPACE (eLife, 2022)
• Home | CALERIE
• American Federation for Aging Research+1
• The Documentary “Don’t Die: The Man Who Wants to Live Forever” on Netflix

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