Exposomics, Vibration-of-Effects, and the Future of AI in Health | Metascience Matters #1

Chirag Patel is an Associate Professor of Biomedical Informatics at Harvard Medical School, renowned for his expertise in using computational methods to understand human health and disease from high-throughput data streams. He specializes in understanding the role in the intersection of genetics and environmental exposures (the exposome) in human health, as well as various disease areas such as diabetes, cardiovascular disease, and Alzheimer’s disease.

CONTACT RANDY:

Feedback: metasciencematters@gmail.com

EPISODE LINKS:

Chirag’s Lab: https://www.chiragjpgroup.org/

TEDx talk on the exposome:    • Exposome: decoding human health and diseas...  

OUTLINE:

0:00 - Introduction

0:37 - How do you decide what to work on?

1:57 - Where does metascience fit into your work?

3:57 - Vibration-of-effects analysis

6:41 - How does VoE change how we see existing scientific work?

9:22 - The biggest challenges in the replication crisis within biomedical informatics

11:48 - Environment-wide association study of Type 2 diabetes

15:04 - The exposome

17:30 - Policy vs. precision medicine applications of the exposome

20:09 - The patient exposome

22:38 - HBA1C for diabetes as a bridge to the exposome

23:54 - Broader metascientific issues of the exposome

25:01 - The effects of extreme weather events on human health

29:35 - AI for biomedical informatics, the exposome, metascience

31:19 - Advice for listeners interested in pursuing research like Chirag’s

32:53 - Outro