GLP-1s Aren’t Metabolic Health: How Gut, Hormones, Stress, Muscle, and Cellular Energy Shape Long-Term Weight and Longevity

What if the fatigue, stubborn weight changes, brain fog, inflammation, or burnout you’re experiencing isn’t a failure of willpower, but a signal that your metabolism is under strain? 

In this solo episode, Dr. Taz unpacks what metabolic health actually means in the age of GLP-1 medications. She explains why weight loss alone is not the same as healing, and how focusing only on the scale can quietly erode muscle, gut function, hormonal balance, cellular energy, and nervous system resilience.

You’ll learn why so many people lose weight but still feel exhausted, inflamed, anxious, or disconnected from their bodies. Dr. Taz breaks down the six core metabolic engines that regulate energy, fat storage, blood sugar, hormones, stress response, and longevity, and why ignoring even one of them can stall long-term health.

This episode reframes metabolism as a full body system. One that includes the gut microbiome, hormone signaling, mitochondrial function, liver detoxification, muscle health, and the nervous system. When these systems fall out of sync, weight becomes a symptom, not the root issue.

Dr. Taz shares:
 • Why GLP-1 medications support weight loss but do not repair metabolic dysfunction
 • How up to 25% of weight lost on GLP-1s can come from muscle, impacting long-term health and longevity
 • Why the gut is the foundation of metabolic health and how digestion, bile flow, and microbiome balance shape hormones and inflammation
 • How hormone shifts, especially in midlife, can rapidly disrupt blood sugar, cholesterol, energy, and weight
 • The role of cellular and mitochondrial health in fatigue, brain fog, and metabolic slowdown
 • Why liver function is central to detoxification, fat metabolism, and insulin regulation
 • How stress and nervous system dysregulation can drive cravings, poor sleep, and metabolic instability
 • How to identify which metabolic engine needs attention first so your plan stays targeted and sustainable

Whether you’re currently on a GLP-1, considering one, struggling after coming off, or simply want to build metabolic health that lasts for decades, this episode offers a grounded, integrative roadmap. You don’t need to chase trends or stack solutions. You need to understand the system you’re living in.

You may not control every variable that shaped your metabolism, but you can change how it functions moving forward.

Stay Connected:

Connect further to Hol+ at https://holplus.co/- Don’t forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.

Follow Dr. Taz on Instagram: 

https://www.instagram.com/drtazmd/

https://www.instagram.com/liveholplus/

Subscribe to the audio podcast: https://holplus.transistor.fm/subscribe

Subscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcasts

Get your copy of The Hormone Shift: Balance Your Body and Thrive Through Midlife and Menopause

Host & Production Team

Host: Dr. Taz; Produced by ClipGrowth.com (Producer: Pat Gostek)