This Week in Pediatric Oncology
Science
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Fd1flMgbfLw
Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Lisa Diller from Dana-Farber/Boston Children's Cancer and Blood Disorders Center. Dr. Diller discusses the possibilities of genetic testing for pediatric cancer predisposition syndromes in newborn screening programs, but with uncertain benefits and costs. She recently authored a paper exploring mathematical modeling of a screening program for cost and benefit.
You can read her full paper here: https://pubmed.ncbi.nlm.nih.gov/33767345/
----more----EXCERPT: We developed a simulation model to evaluate universal screening for a CPS panel. Cohorts of US newborns were simulated under universal screening versus usual care. Using data from clinical studies, ClinVar, and gnomAD, the presence of pathogenic/likely pathogenic (P/LP) variants in RET, RB1, TP53, DICER1, SUFU, PTCH1, SMARCB1, WT1, APC, ALK, and PHOX2B were assigned at birth. Newborns with identified variants underwent guideline surveillance. Survival benefit was modeled via reductions in advanced disease, cancer deaths, and treatment-related late mortality, assuming 100% adherence.
----more----Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org.
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TWiPO #110: Discussing the ”Gift from a Child” Program with Al Gustafson & Dr. Angela Waanders
TWiPO #109: Discussing the Early Detection of Cancer Using Genomics with Dr. Trevor Pugh
TWiPO #108: Hepatoblastoma: A Physician & Patient Family’s Story with Dr. Jim Geller & The Woolwines
TWiPO #107: Discussing the International rEECur Trial for Ewing Sarcoma with Dr. Martin McCabe
TWiPO #106: Genetic Predisposition in Childhood Cancer with Dr. Garrett Brodeur
TWiPO #105: How to Build a Pediatric Cancer Disease Community with Ann Graham
TWiPO #104: PEEL Therapeutics - Nanotechnology for Pediatric Cancer with Dr. Joshua Schiffman
TWiPO #103: Focused Ultrasound Therapy for Pediatric Brain Tumors with Dr. Roger Packer
TWiPO #102: Inequity in Pediatric Cancer Trials and Outcomes with Dr. Douglas Hawkins
TWiPO #101: An Update on the NCI Pediatric MATCH Trial with Dr. Will Parsons
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TWiPO #99: Update on the Pediatric Cancer Data Commons and GEARBOx with Dr. Samuel Volchenboum
TWiPO #98: Reflections on a Long, Distinguished Career & Future Perspectives with Dr. Jonathan Finlay
TWiPO #97: GD2-CAR T Cell Therapy for H3K27M-mutated Diffuse Midline Gliomas with Dr. Robbie Majzner
TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse
TWiPO #95: Patient Advocates’ Views in Neuroblastoma with Nick Bird & Donna Ludwinski
TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman
TWiPO #93: CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas Orentas
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