Discussing the FRBM special issue 'Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases' published in the September 2022 issue of the journal.
Speaker: Dr. Elias Arner, Karolinska Institutet, Sweden
Moderator: Prof. Henry J Forman, University of Southern California, USA
0:44 Introduction of Dr. Elias Arner
1:30 How and why Dr. Arner moved into selenium and thioredoxin research
6:48 Activities of TrxR and its multiple domains
10:18 How substitution of sulfurs in selenium results in a less or completely inactive thioredoxin reductase
16:25 Reduction of small molecules - is that just a lab curiosity or physiologically significant?
18:34 The good and the bad of modulating thioredoxin reductase activity
26:30 How there's a critical role for thioredoxin reductase in parasites
31:20 When you use thioredoxin reductase inhibitors in diseases, how do you go about it in a way that does not cause havoc?
34:35 Speculation on why there are 25 seleno proteins identified in animals but the activity of many of them remains a mystery
38:02 Advice for young investigators
41:06 Dr. Arner's work outside of science as an artist and writer
Oxidative Stress Responses in Plants
Bench to bedside transition for pharmacological regulation of NRF2 in non-communicable diseases
Lipid Peroxidation in Alzheimer’s Disease
Hidden Networks of Aberrant Protein Transnitrosylation Contribute to Synapse Loss in Alzheimer’s Disease
Mitochondrial Redox Signaling in Aging-Related Diseases
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