In recent years it has become more and more evident, that genome folding and chromatin packaging into the nucleus plays a pivotal role in the regulation of gene expression. In this Episode of our Podcast our host Dr. Stefan Dillinger spoke with Professor Wendy Bickmore about her work on the spatial organization of the human genome. Prof. Bickmore and her team mainly use visual methods like fluorescence in situ hybridisation (FISH) to study the organization of chromosomes in human and murine cells and how they contribute to transcriptional regulation and how this organization changes during ageing, development or disease.
References
Contact
The Impact of Sequence Variation on Transcription Factor Binding (Sven Heinz)
Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples (Sarah Marzi)
The Role of Hat1p in Chromatin Assembly (Mark Parthun)
The Impact of Paternal Diet on Offspring Metabolism (Upasna Sharma)
H3K36me3, H4K16ac and Cryptic Transcription in Ageing (Weiwei Dang)
Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)
MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)
Sex-biased Imprinting and DNA Regulatory Landscapes During Reprogramming (Sam Buckberry)
BET Proteins and Their Role in Chromosome Folding and Compartmentalization (Kyle Eagen)
Epigenetic Underpinnings of Human Addiction (Francesca Telese & Jessica Zhou)
H3K79 Methylation, DOT1L, and FOXG1 in Neural Development (Tanja Vogel)
Function of Insulators in 3D Genome Folding (Maria Gambetta)
Contribution of the Estrogen Receptor to Breast Cancer Progression (Jason Carroll)
Inheritance of Transcriptional Memory by Mitotic Bookmarking (Sheila Teves)
Differential Methylated Regions in Autism Spectrum Disorders (Janine La Salle)
DNA Damage in Longevity and Ageing (Björn Schumacher)
The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)
Long-Range Transcriptional Control by 3D Chromosome Structure (Luca Giorgetti)
Transgenerational Inheritance and Epigenetic Imprinting in Plants (Mary Gehring)
When is a Peak a Peak? (Claudio Cantù)
Create your
podcast in
minutes
It is Free
DNA Today: A Genetics Podcast
Museum of the Missing
Strange by Nature Podcast
Sasquatch Chronicles
Hidden Brain