This Week in Pediatric Oncology
Science
April 25, 2011
In this third episode, host Tim Cripe, MD, PhD, asks his co-hosts to discuss two recent papers that provide new information about genetic predisposition to increased toxicity to vincristine in some children, and the results of a phase II study using a combination therapy (irinotecan and temozolomide) in relapsed or refractory neuroblastoma.
1:24 Maureen O'Brien, MD discusses "Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia" in Pediatr Blood Cancer. 2011 Mar;56(3):361-7. doi: 10.1002/pbc.22845. Epub 2010 Nov 11.http://www.ncbi.nlm.nih.gov/pubmed/21225912
22:10 Lars Wagner, MD discusses "Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: a Children's Oncology Group study" from J Clin Oncol. 2011 Jan 10;29(2):208-13. Epub 2010 Nov 29. http://www.ncbi.nlm.nih.gov/pubmed/21115869
New Focused Ultrasound Study for Progressive Diffuse Midline Glioma
TWiPO #111: A Discussion on Oncofertility/Fertility Preservation with Dr. Seth Rotz
TWiPO #110: Discussing the ”Gift from a Child” Program with Al Gustafson & Dr. Angela Waanders
TWiPO #109: Discussing the Early Detection of Cancer Using Genomics with Dr. Trevor Pugh
TWiPO #108: Hepatoblastoma: A Physician & Patient Family’s Story with Dr. Jim Geller & The Woolwines
TWiPO #107: Discussing the International rEECur Trial for Ewing Sarcoma with Dr. Martin McCabe
TWiPO #106: Genetic Predisposition in Childhood Cancer with Dr. Garrett Brodeur
TWiPO #105: How to Build a Pediatric Cancer Disease Community with Ann Graham
TWiPO #104: PEEL Therapeutics - Nanotechnology for Pediatric Cancer with Dr. Joshua Schiffman
TWiPO #103: Focused Ultrasound Therapy for Pediatric Brain Tumors with Dr. Roger Packer
TWiPO #102: Inequity in Pediatric Cancer Trials and Outcomes with Dr. Douglas Hawkins
TWiPO #101: An Update on the NCI Pediatric MATCH Trial with Dr. Will Parsons
This Week in Pediatric Oncology - 100th Episode
TWiPO #99: Update on the Pediatric Cancer Data Commons and GEARBOx with Dr. Samuel Volchenboum
TWiPO #98: Reflections on a Long, Distinguished Career & Future Perspectives with Dr. Jonathan Finlay
TWiPO #97: GD2-CAR T Cell Therapy for H3K27M-mutated Diffuse Midline Gliomas with Dr. Robbie Majzner
TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse
TWiPO #95: Patient Advocates’ Views in Neuroblastoma with Nick Bird & Donna Ludwinski
TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman
TWiPO #93: CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas Orentas
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