This Week in Pediatric Oncology
Science
July 12, 2011
In this eleventh episode of "This Week in Pediatric Oncology" hosts Dr. Tim Cripe and Dr. Lars Wagner discuss with guest Dr. Brian Weiss (Cincinnati Children's Hospital) the implications of the recent results comparing two chemotherapy combinations for transplant regimens in children with high-risk neuroblastoma in Europe. The BuMel (busulfan, melphalan) regimen resulted in better survival and lower toxicity than CEM (carboplatin, etoposide, melphalan), a regimen used for transplant in the COG for a decade.
This SIOP trial was one of the plenary presentations at ASCO in June 2011. In this lively and informative discussion, Dr. Brian Weiss explains the COG response to these results due to the difference in induction regimens. The BuMel regimen will be used in the upcoming MIBG frontline pilot that Dr. Weiss is leading as principal investigator.
Dr. Weiss and TWiPO hosts also discussed the recent paper Safety and efficacy of tandem (131) I-metaiodobenzylguanidine infusions in relapsed/refractory neuroblastoma authored by Johnson et al in Pediatr Blood Cancer. 2011 Apr 14
Please send questions and comments to twipo@solvingkidscancer.org
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TWiPO #111: A Discussion on Oncofertility/Fertility Preservation with Dr. Seth Rotz
TWiPO #110: Discussing the ”Gift from a Child” Program with Al Gustafson & Dr. Angela Waanders
TWiPO #109: Discussing the Early Detection of Cancer Using Genomics with Dr. Trevor Pugh
TWiPO #108: Hepatoblastoma: A Physician & Patient Family’s Story with Dr. Jim Geller & The Woolwines
TWiPO #107: Discussing the International rEECur Trial for Ewing Sarcoma with Dr. Martin McCabe
TWiPO #106: Genetic Predisposition in Childhood Cancer with Dr. Garrett Brodeur
TWiPO #105: How to Build a Pediatric Cancer Disease Community with Ann Graham
TWiPO #104: PEEL Therapeutics - Nanotechnology for Pediatric Cancer with Dr. Joshua Schiffman
TWiPO #103: Focused Ultrasound Therapy for Pediatric Brain Tumors with Dr. Roger Packer
TWiPO #102: Inequity in Pediatric Cancer Trials and Outcomes with Dr. Douglas Hawkins
TWiPO #101: An Update on the NCI Pediatric MATCH Trial with Dr. Will Parsons
This Week in Pediatric Oncology - 100th Episode
TWiPO #99: Update on the Pediatric Cancer Data Commons and GEARBOx with Dr. Samuel Volchenboum
TWiPO #98: Reflections on a Long, Distinguished Career & Future Perspectives with Dr. Jonathan Finlay
TWiPO #97: GD2-CAR T Cell Therapy for H3K27M-mutated Diffuse Midline Gliomas with Dr. Robbie Majzner
TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse
TWiPO #95: Patient Advocates’ Views in Neuroblastoma with Nick Bird & Donna Ludwinski
TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman
TWiPO #93: CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas Orentas
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