This Week in Pediatric Oncology
Science
August 05, 2011
Host Dr. Tim Cripe and co-host Maureen O’Brien discuss recent papers on immunotherapy and DNA sequencing studies revealing new potential targets in acute lymphoblastic leukemia (ALL).
1:45 min. Results on use of BiTE antibody (Bi-specific T-cell engaging) blinatumomab in adults with lymphoma and leukemia:
Exp Cell Res. 2011 May 15;317(9):1255-60. Epub 2011 Mar 16. Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab
J Clin Oncol. 2011 Jun 20;29(18):2493-8. Epub 2011 May 16. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.
Use of blinatumomab in pediatrics was recently reported in Germany, and an international phase I/II trial for pediatrics is due to begin accruing this year.
Leukemia. 2011 Jan;25(1):181-4. Epub 2010 Oct 14. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia.
23:00 min. Recent findings from the TARGET Initiative (Therapeutically Applicable Research to Generate Effective Treatments) http://target.cancer.gov/
Through NIH's TARGET initiative, scientists sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute lymphoblastic leukemias (HR B-ALL) and normal tissues and combined the results with data from previous studies using microarry and gene copy number studies. Sorting through this massive amount of information revealed a high frequency of recurrent genetic alterations in several specific cancer signaling pathways. The information appears to be useful to stratify these patients into subcategories, some of whom do much better than others. These data highlight potential new therapeutic targets in certain subsets of childhood ALL.
Blood. 2010 Dec 2;116(23):4874-84. Epub 2010 Aug 10. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
Blood. 2011 Jun 16. [Epub ahead of print] Key pathways are frequently mutated in high risk childhood acute lymphoblastic leukemia: a report from theChildren's Oncology Group
Please send all questions or comments to twipo@solvingkidscancer.org
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TWiPO #111: A Discussion on Oncofertility/Fertility Preservation with Dr. Seth Rotz
TWiPO #110: Discussing the ”Gift from a Child” Program with Al Gustafson & Dr. Angela Waanders
TWiPO #109: Discussing the Early Detection of Cancer Using Genomics with Dr. Trevor Pugh
TWiPO #108: Hepatoblastoma: A Physician & Patient Family’s Story with Dr. Jim Geller & The Woolwines
TWiPO #107: Discussing the International rEECur Trial for Ewing Sarcoma with Dr. Martin McCabe
TWiPO #106: Genetic Predisposition in Childhood Cancer with Dr. Garrett Brodeur
TWiPO #105: How to Build a Pediatric Cancer Disease Community with Ann Graham
TWiPO #104: PEEL Therapeutics - Nanotechnology for Pediatric Cancer with Dr. Joshua Schiffman
TWiPO #103: Focused Ultrasound Therapy for Pediatric Brain Tumors with Dr. Roger Packer
TWiPO #102: Inequity in Pediatric Cancer Trials and Outcomes with Dr. Douglas Hawkins
TWiPO #101: An Update on the NCI Pediatric MATCH Trial with Dr. Will Parsons
This Week in Pediatric Oncology - 100th Episode
TWiPO #99: Update on the Pediatric Cancer Data Commons and GEARBOx with Dr. Samuel Volchenboum
TWiPO #98: Reflections on a Long, Distinguished Career & Future Perspectives with Dr. Jonathan Finlay
TWiPO #97: GD2-CAR T Cell Therapy for H3K27M-mutated Diffuse Midline Gliomas with Dr. Robbie Majzner
TWiPO #96: GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse
TWiPO #95: Patient Advocates’ Views in Neuroblastoma with Nick Bird & Donna Ludwinski
TWiPO #94: Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman
TWiPO #93: CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas Orentas
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