Welcome to the seventh episode of From Paper to Practice, a podcast series of the World Stroke Academy and the International Journal of Stroke. Join Dr. Christine Tunkl and Megan Ritson as they discuss the relationship between illicit drug use and stroke risk. Drawing on findings from a recent review, this episode explores the increased risk of stroke associated with amphetamines, cocaine, and cannabis, the potential biological mechanisms involved, and the implications for clinical practice and future research. The discussion also addresses the global burden of substance misuse and the challenges of studying this important but often under-recognized contributor to stroke. Tune in for an insightful discussion on an increasingly relevant topic in stroke prevention, clinical care, and public health.