Science Will Win

Part 4 — From Discovery to Delivery: How Scientists Are Revolutionizing Cancer Treatment

In drug discovery and development, every part of the process matters. Scientists learn from every experiment and every observation. In fact, some of the most cutting-edge advancements in medicine are being dreamed up from findings uncovered in the past.  In this episode, co-hosts Dr. Raven Baxter and Dr. Ronald Gamble dive deep into antibody drug conjugates, a groundbreaking modality that uses targeted antibody engineering to deliver potent chemotherapy directly to cancer-causing cells. They explore the complex ADC creation process and learn how ADCs are changing the standard of care for bladder cancer, from someone with a personal relationship to the disease.Featured Guests:– Renee Barron-Gores, Caregiver– Phoenix Ho, Vice President, Oncology Early Clinical Development, Pfizer– Sharsti Sandall, Executive Director, ADC Biology, Oncology Research Unit, PfizerDive into the episode here:1:16 - Old ideas yield new discoveries3:01 - How do antibody drug conjugates work?5:07 - The origins of ADCs8:36 - ADCs allow for more targeted cancer treatment10:44 - How are ADCs structured?14:16 - How do scientists find the best ADC combinations?18:27 - Developing oncology drugs22:02 - ADCs and bladder cancer24:28 - A caregiver’s perspective on cancer treatment38:12 - Science Will WinSeason 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Part 3 — Getting Attached to Molecular Glues

Protein-protein interactions facilitate numerous bodily processes – everything from the basics of how our muscles contract to the more complex ways cancer can spread through the body. So, what if there was a way to alter some of these interactions? Or even create new ones?In this episode, we’re diving into the fascinating field of molecular glues, a revolutionary modality on the precipice of changing the treatment landscape for certain cancers and potentially other diseases and conditions. Featured Guests:– Joyann Donaldson, Principal Scientist, Synthesis Group Lead, Pfizer– Jennifer LaFontaine, Head of Oncology Medicinal Chemistry, Pfizer– Neal Sach, Research Fellow, Pfizer– Jillian Spangler, Associate Research Fellow, PfizerDive into the episode here:0:50 - A metaphor to explain molecular glues2:36 - How do molecular glues work in the body?5:57 - A new frontier for cancer treatment 13:05 - The history behind molecular glues16:59 - How do scientists design molecular glues?19:05 - A visit to Pfizer’s La Jolla labs32:42 - How can molecular glues change the patient experience?36:42 - Molecular glues beyond cancer treatmentSeason 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Part 2 — The Mighty, Multifaceted Molecule

The next frontier of medicine is focused on highly targeted drug therapies that could expand the possibilities of individualized patient care. Today, scientists are working on a particular type of molecule that could harness multiple capabilities and treat inflammatory and autoimmune diseases in ways never done before. In this episode, co-hosts Dr. Raven Baxter and Dr. Ronald Gamble explore how the latest advancements in antibody engineering led to multispecific antibodies—powerhouse molecules that can do the jobs of multiple drugs in one. They learn all about what it takes to assemble these antibodies and the impact they could make on patients—with a patient.  Featured Guests:– Emma Guttman, Chair of the Department of Dermatology, Icahn School of Medicine at Mount Sinai– Amanda Lopez, Patient, Texas Ambassador for the National Eczema Association– Laird Bloom, Senior Director of Biomedicine Design, Pfizer– Thomas Wynn, Vice President of Discovery, Inflammation & Immunology, PfizerDive into the episode here:1:12 - A metaphor for multispecific antibodies4:08 - How do multispecific antibodies work?10:39 - The history behind multispecific antibodies16:29 - How are multispecific antibody drugs are made?22:58 - An eczema expert on the potential of multispecific antibodies29:30 - Amanda Lopez's eczema story40:14 - What's next, and closing thoughtsSeason 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Part 1 — The Case of the Missing Vaccine

Medical advancements don’t just spring up—they happen by building on decades of previous discoveries. Today, one of these advancements might be on the verge of another breakthrough. But what had to happen first for it to exist?In this episode, co-hosts Dr. Raven Baxter and Dr. Ronald Gamble explore how a vaccine candidate for a deadly, once-mysterious bacterial disease came to be. The story takes them from one doctor’s groundbreaking connection in the 70s, all the way to a real lab where vaccines are being developed today.Featured Guests:– Carol Baker, Pediatric Infectious Disease Specialist– Isis Kanevsky, Senior Director, Vaccines, Pfizer– Ksenia Krylova, Senior Director, Vaccines, PfizerDive into the episode here:02:54 - Getting into the problem05:11 - The basics of immunity and vaccine science09:32 - What is a conjugate vaccine?14:44 - Group B Strep: A case study22:23 - Talking to a GBS pioneer31:40 - A trip to the lab43:08 - What's next, and closing thoughtsSeason 5 of Science Will Win is created by Pfizer and hosted by Dr. Raven Baxter and Dr. Ronald Gamble. It’s produced by Acast Creative Studios.Check out our social media platforms to take a deeper look into the labs and stories we discuss during the episodes: Instagram (@pfizerinc), TikTok (@pfizer) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Coming Soon – Science Will Win Season 5: A new journey through drug discovery

Science Will Win is back for a new season, with new hosts and a new format. Now, science educators Dr. Raven Baxter a molecular biologist otherwise known as Raven, the Science Maven, and Dr. Ronald Gamble, a theoretical astrophysicist at NASA, are teaming up to explore four exciting medical technologies. These technologies are right on the cusp of a potentially groundbreaking moment, either unlocking our ability to tackle new diseases or allowing us to tackle old ones in ways we never could before. This journey takes our hosts through discussions with cutting edge researchers, stories of medical mysteries solved, and tours of real labs that are used every day in the quest to create new medicines. Tune in to the latest four-part season, coming soon! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.