George Perry: Oxidative Stress and Synaptic Dysfunction in Alzheimer’s Disease

Because neurons are very active cells they consume high amounts of oxygen and produce high amounts of oxygen free radicals (oxyradicals). Because most neurons in the brain exist throughout life and cannot be replaced it is critical that they be able to efficiently remove oxyradicals and repair damage caused to DNA, proteins and membranes caused by oxyradicals. During normal aging and moreso in Alzheimer’s disease neurons accumulate oxidative damaged molecules and mitochondria. In this episode professor George Perry talks about oxidative stress and its roles in synaptic dysfunction and neuronal degeneration in Alzheimer’s disease. He also talks about approaches to preventing and treating Alzheimer’s disease based on holistic rather than targeted interventions. 

LINKS:

Review articles:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091392/pdf/nihms288394.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451948/pdf/antioxidants-12-01628.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452017/pdf/EMBJ-36-1474.pdf