Do You Need to Stay on GLP-1s Forever? The Truth About Hormones, Weight, and What Happens When You Stop | Ep 305

2025-10-08

In this episode, Stephanie breaks down a recent Tik Tok comment:“It’s a hormone issue - you have to stay on GLP-1s forever.”With millions of people using medications like Ozempic, Wegovy, and Mounjaro, it’s no surprise that many are wondering what really happens when you come off. Stephanie explores the science, the psychology, and the truth behind long-term GLP-1 use - including why most people can’t (and shouldn’t have to) stay on them for life.You’ll learn:How GLP-1s work in the body and brainWhat clinical studies show about weight regain after stoppingWhy “hormones only” is an ove...

In this episode, Stephanie breaks down a recent Tik Tok comment:

“It’s a hormone issue - you have to stay on GLP-1s forever.”

With millions of people using medications like Ozempic, Wegovy, and Mounjaro, it’s no surprise that many are wondering what really happens when you come off. Stephanie explores the science, the psychology, and the truth behind long-term GLP-1 use - including why most people can’t (and shouldn’t have to) stay on them for life.

You’ll learn:

How GLP-1s work in the body and brain

What clinical studies show about weight regain after stopping

Why “hormones only” is an oversimplification

How to manage appetite, mood, and mindset when coming off

Evidence-based strategies to support your mental health and eating patterns post-GLP-1

If you’re on a GLP-1, considering one, or transitioning off and struggling with hunger or emotional eating - this episode will help you understand your body and brain without guilt or fear.

Disclaimer: This podcast is for educational purposes only and does not substitute professional medical advice, diagnosis, or treatment. The content in this episode is based on current research and clinical experience but should not replace consultation with your doctor or psychologist. Do not discontinue or adjust any medication without speaking to your prescribing physician.

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