Kicking Alzheimer’s Butt & Your Questions with Dr. Richard Isaacson

2026-05-05

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If you’ve been following along, you know Penn recently found out he has two copies of the APOE4 gene - basically the “high risk” genetic lottery for Alzheimer’s. And while we thought we were prepared for that news… we weren’t. It hit hard. For both of us. But this episode is not about fear. It’s about hope.This week we are sitting down (again!) with Dr. Richard Isaacson (the brain behind Penn’s prevention plan and one of the leading voices in Alzheimer’s prevention) to answer YOUR questions. And wow, did you have ques...

This week we are sitting down (again!) with Dr. Richard Isaacson (the brain behind Penn’s prevention plan and one of the leading voices in Alzheimer’s prevention) to answer YOUR questions. And wow, did you have questions. We discuss what to actually ask your doctor, what Penn is doing right now, prevention strategies that are showing promise, and how close we are to affordable, at-home Alzheimer’s risk testing. Spoiler: closer than you’d expect. But the biggest thing we discuss? Why genes are not your destiny.

We also get very real about the emotional side of this, like what it’s like to love someone who might face this disease, what caregiving actually looks like, and why doing something now matters so much. If you or someone you love has concerns about Alzheimer's, this show is for you. Because for the first time, this doesn’t feel like a ticking time bomb. It feels like something we can actually fight. We love to hear from you! Leave us a message at 323-364-3929 or write the show at podcast@theholdernessfamily.com. You can also watch our podcast on YouTube.

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Laugh Lines with Kim & Penn Holderness is an evolution of The Holderness Family Podcast, which began in 2018. Kim and Penn Holderness are award-winning online content creators known for their original music, song parodies, comedy sketches, and weekly podcasts. Their videos have resulted in over three billion views and over nine million followers since 2013. Penn and Kim are also authors of the New York Times Bestselling Books, ADHD Is Awesome: A Guide To (Mostly) Thriving With ADHD and All You Can Be With ADHD. They were also winners on The Amazing Race (Season 33) on CBS.

Laugh Lines is hosted and executive produced by Kim Holderness and Penn Holderness, with original music by Penn Holderness. Laugh Lines is also written and produced by Ann Marie Taepke, and edited and produced by Sam Allen. It is hosted by Acast. Thanks for listening!

Hosted on Acast. See acast.com/privacy for more information.

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