Male mice can grow female organs — if their mothers lack iron
Nature Podcast

Male mice can grow female organs — if their mothers lack iron

2025-06-04
00:45 Iron’s role in mice sex determinationIron deficiency in mice mothers can sometimes result in their offspring developing female sex organs despite having male sex genes, according to new research. While genetics has been thought to be the primary factor in determining offspring sex in mammals, the new work shows that a lack of iron disrupts an enzyme involved in the development of testes, leading to some mice with male sex-determining genes being born with female genitalia and ovaries. This suggests that sex determination is controlled by more than g...
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