Niacin for Anxiety, Schizophrenia, and Mania

In this episode we discuss niacin (vitamin B3), and how it helps counter brain overstimulation and so, anxiety, mania, and schizophrenia. We also talk about the use of B3 for confusion, learning disorders, dementia, and nicotine and alcohol  withdrawal.

Books
Hoffer A, Saul AW. (2015) Niacin: The Real Story, Basic Health Pub, Inc.
Hoffer A, Adventures in Psychiatry: The Scientific Memoirs of Dr Abram Hoffer.
Edelman, E, Natural Healing for Schizophrenia, and Natural Healing for Bipolar Disorder

A couple of Dr. Hoffer's early studies
Hoffer A, Osmond H, Smythies J. (1954) Schizophrenia; a new approach. II. Result of a year's research. J Ment Sci. 100:29-45.
Hoffer, A., Osmond, H., Callbeck, M. J., & Kahan, I. (1957). Treatment of schizophrenia with nicotinic acid and nicotinamide. Journal of Clinical and Experimental Psychopathology, 18(2), 131-157. 

NIACIN and dementia
M Morris, D Evans, Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline, J Neurol Neurosurg Psychiatry. 2004; Aug; 75(8): 1093–99.
Moutinho, M., et al. (2022) The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease. Science Translational Medicine, Vol. 14, No. 637.

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