Why You’re Gaining Weight in Midlife: Ozempic, Muscle Loss, and Longevity | Dr. Mary Pardee

Midlife weight gain is often blamed on a “slowing metabolism.” But the science tells a different story.

Between ages 20 and 60, your metabolism barely changes. What does change? Muscle mass. Exercise habits. Hormonal signaling. Cardiovascular risk. And increasingly, the conversation around GLP-1 medications like Ozempic.

In this episode, we unpack the real drivers of midlife weight gain, the surprising data on muscle loss and mortality, the nuanced role of GLP-1 drugs in long-term health, and what actually improves lifespan and healthspan.

If you’ve wondered:

• Is my metabolism broken?

• Is Ozempic helping or hurting long term?

• Why is muscle suddenly such a big deal?

• What actually prevents heart disease and dementia?

This episode connects the dots.

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