Beyond Leaky Gut: Clinical Guidelines for Intestinal Permeability with Dr. Brad Leech

In this episode, Dr Brad Leech shares the exclusive results of his PhD research, which produced the first comprehensive clinical practice guidelines for intestinal permeability. 

Dispelling common myths about "leaky gut syndrome," Dr Leech explains why intestinal hyperpermeability is a legitimate physiological reaction—not a syndrome—and how his meticulously developed, evidence-based guidelines can transform clinical practice.

This episode provides invaluable insights into the following:

• The rigorous methodology behind developing clinical practice guidelines, including stakeholder engagement, comprehensive literature review, and systematic evaluation of over 10,000 research articles
• The critical importance of risk-of-bias assessment when evaluating research—a cornerstone of methodology that helps practitioners look beyond cherry-picked studies and misleading claims
• How to systematically evaluate research quality by examining randomization procedures, analysis methods, conflict of interests and  clinical relevance rather than accepting published findings at face value
• Surprising findings about commonly used interventions in intestinal permeability, including evidence that certain probiotics may not be effective for NSAID-induced permeability despite their widespread recommendation
• Evidence-based assessment of treatments for intestinal permeability using the NHMRC grading matrix to evaluate research quality
• Practical recommendations and evidence-supported interventions that meet the threshold for clinical relevance

Dr Leech's work represents a significant advancement in the field, bringing scientific rigour to an area often clouded by opinion and marketing claims.

 Learn how these new guidelines can help you make more informed clinical decisions and improve patient outcomes through evidence-based approaches to intestinal permeability.

Connect with Dr Leech: Dr Brad Leech

Read: The IP Guideline

Shownotes and references are available on the Designs for Health website


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DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health