How does the gut-brain connection work?

Gut feelings, trusting your gut, butterflies: We have lots of expressions about how our brains and our bowels are intertwined. But how well do we understand the science of this on the biomolecular level? And which of those organs is actually in the driver's seat? 

Flora churned through the details with gastroneurologists Emeran Mayer and Trischa Pasricha on stage at the 2026 Aspen Ideas Festival in Colorado. 

Guests:

Dr. Emeran Mayer is distinguished research professor at the David Geffen School of Medicine at UCLA, and executive director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience.

Dr. Trisha Pasricha is a neurogastroenterologist and physician-scientist at Beth Israel Deaconess Medical Center as well as an assistant professor of medicine at Harvard Medical School.

Other episodes you may enjoy:

• How to poop better, according to a gastroenterologist
• The Gurgling, Growling History Of The Gut

A transcript for this episode is available at sciencefriday.com.

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