Mast Cells: Friend or Foe? with Dr. Theoharis Theoharides (Ep 151)

2025-06-26

What if your brain fog, fatigue, and hypersensitivity weren’t “just anxiety”—but signs of a much deeper immune malfunction? In this episode, Dr. Pradeep Chopra co-hosts a rare and revealing conversation with Dr. Theoharis Theoharides, the scientist who first discovered that mast cells communicate with microglia in the brain. Together, they dive into groundbreaking research on neuroinflammation, autism, histamine, stress, and why brain fog may not be “all in your head”—but inflammation inside it. From overlooked biomarkers to misunderstood...

What if your brain fog, fatigue, and hypersensitivity weren’t “just anxiety”—but signs of a much deeper immune malfunction?

In this episode, Dr. Pradeep Chopra co-hosts a rare and revealing conversation with Dr. Theoharis Theoharides, the scientist who first discovered that mast cells communicate with microglia in the brain. Together, they dive into groundbreaking research on neuroinflammation, autism, histamine, stress, and why brain fog may not be “all in your head”—but inflammation inside it.

From overlooked biomarkers to misunderstood triggers, this episode unpacks the science most doctors still don’t know… but patients desperately need

Takeaways:

What you didn’t know about the link between stress and mast cell activation in the brain.
A surprising breakdown of how mast cells could be fueling neuroinflammation and foggy thinking.
Why autism and MCAS might share more than we think—especially in early development.
The overlooked role of environmental stressors in triggering immune responses that affect cognition.

How one researcher’s journey into mast cells rewrote everything we thought we knew about inflammation.

Fine the episode transcript here.

Want more Dr. Theoharis Theoharides?

Website: https://www.drtheoharides.com/
Podcast Link: https://algonot.com/
Blogs: https://www.nova.edu/nim/neuroinflammation-research/index.html
LinkedIn: https://www.linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735

Want more Dr. Pradeep Chopra?

Website: https://www.painri.com/

Reference Episodes:

Episode 70: https://youtu.be/BoRyQh12X2c
Episode 71: https://youtu.be/yDT3JTzfiJk
Episode 72: https://youtu.be/CYhnKkVjIxM
Episode 73: https://youtu.be/2OxtZGNswfo
Episode 77: https://youtu.be/d9A1aJB5GRo

Episode 139: https://youtu.be/u1pxvAzXh7M

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