Last month the FDA approved a new treatment for sickle cell disease, the first medical therapy to use CRISPR gene editing technology. It works by identifying the gene or genes causing the disorder, modifying those genes and then returning them to the patient’s body.
There are now two gene therapies offered by pharmaceutical companies for sickle cell disease: Casgevy from Vertex Pharmaceuticals and CRISPR Therapeutics, and Lyfgenia from BlueBird Bio. But prices for these one-time treatments are steep: Casgevy costs $2.2 million per patient and Lyfgenia $3.1 million.
Both promise a full cure, which would be life-changing for patients with this debilitating condition. Over 100,000 Americans, mostly of African descent, have sickle cell disease.
This milestone raises more questions: What will be the next disease that CRISPR can help cure? And is it possible to reduce the costs of gene therapy treatments?
Ira talks with Dr. Fyodor Urnov, professor of molecular and cell biology and scientific director of technology and translation at the Innovative Genomics Institute, based at the University of California, Berkeley, about the future of CRISPR-based cures.
Transcripts for this segment will be available the week after the show airs on sciencefriday.com.
To stay updated on all things science, sign up for Science Friday's newsletters.
641: How A Deaf Advisory Group Is Changing Healthcare
643: 40 Years Of Sounding The Alarm On Nuclear Winter
640: CRISPR-Based Sickle Cell Treatment | Pain Tolerance From Neanderthals
637: How Poisons Have Shaped Life On Earth
635: Placenta Research May Help Explain Pregnancy Loss
634: A Common Cold Medicine Ingredient Doesn’t Work. What Now?
633: Diving Into Elon Musk’s Mind
636: RSV Drug Shortage & Beech Leaf Disease
632: When Studying Ecology Means Celebrating Its Gifts
632: Unlocking The Mysteries Of A Metal-Rich Asteroid
631: Rapidly Evolving Trout & Ancient Hyper-Apex Predators
630: Finding Meaning In The Cosmos
630: ‘Clean Hydrogen Hub’ Awardees & Formula One Car Paint
628: What Is Your Cat Doing When You're Not Watching?
629: The Stories Of The First Six Women Astronauts
627: A Mathematician Asks ‘Is Math Real?’
628: The mRNA Vaccine Revolution
626: Ancient Human Footprints & 'Ring Of Fire' Eclipse
623: Saltwater Wedge In The Mississippi & Kenya's Geothermal Boom
625: How Artists And Scientists Collaborated To Make Art About HIV
Create your
podcast in
minutes
It is Free
The Modern West
Voices of Misery Podcast
House of Whimsical Terror
Dairyland Frights
Stuff You Should Know
Timcast IRL