How to Lose Weight When You Are Insulin Resistant

In this episode of the School of Doza podcast, Nurse Doza discusses how to lose weight when you are insulin resistant. He starts by emphasizing the commitment needed to make these changes and encourages listeners to sign up for the newsletter on MSWLounge.com for weekly content and advice. Nurse Doza then explains that insulin resistance is common and leads to inflammation, and provides specific changes that can help with weight loss.

 

TIMESTAMPS:

00:00 Start

02:25 Insulin resistance and weight gain.

04:21  Insulin Resistance and Diabetes.

08:02 Leptin Resistance and Weight Loss.

11:50 Brown fat and weight loss.

19:42 Insulin resistance and weight loss.

24:29 Activation of parasympathetic nervous system.

27:23 Insulin Resistance and Weight Loss.

31:57 Resveratrol supplement.

 

 

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REFERENCES:

What being insulin resistant means: _inflammation

 

your body is reluctant to release anymore insulin___ (1)

“Insulin resistance is identified as an impaired biologic response to insulin stimulation of target tissues, primarily the liver, muscle, and adipose tissue” (2)

 

“You do not have to be overweight to have insulin resistance” (1) 

 

“The spectrum of disease associated with insulin resistance includes obesity, cardiovascular disease, nonalcoholic fatty liver disease, metabolic syndrome, and polycystic ovary syndrome(PCOS).” (2) 

 

Ways to measure IR: “HOMA-IR, serum triglyceride, and triglyceride/HDL ratio.” (2)

 

**“Insulin resistance is thought to precede the development of T2DM by 10 to 15 years. “ (2)

 

“While no medications are FDA approved for the treatment of insulin resistance” (3) 

“Lifestyle modification should be the primary focus for the treatment of insulin resistance.” (3)

 

References: https://www.cdc.gov/diabetes/basics/insulin-resistance.html (1) 

https://www.ncbi.nlm.nih.gov/books/NBK507839/ (2)

IR: https://www.ncbi.nlm.nih.gov/books/NBK507839/ (3) 

 

Leptin: “Leptin resistance is defined by a reduced sensitivity or a failure in response of the brain to leptin, showing a decrease in the ability of leptin to suppress appetite or enhance energy expenditure, which causes an increased food intake and finally leads to overweight, obesity, cardiovascular diseases, and other metabolic disorders” (1)

 

“A minor increase in leptin concentration reduces the appetite and leads to a decrease in body weight;3 however, in obesity, despite increased leptin concentration, the efficacy of the anorexic effect of leptin is decreased,1,3 with leptin resistance developing due to a defect in intracellular signaling associated with the leptin receptor or decreases in leptin transport across the blood–brain barrier (BBB)” (2)

 

“participation of leptin in the development of cardiovascular and autoimmune diseases and cancer” (2) 

References: leptin: https://pubmed.ncbi.nlm.nih.gov/30390289/ (1)

Leptin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354688/ (2)

IR: https://www.ncbi.nlm.nih.gov/books/NBK507839/ (3)

 

References: leptin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354688/ (1)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815269/ (2) 

https://academic.oup.com/jcem/article/91/12/4753/2656230?login=false (3) 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848049/ (4)

 

References: https://www.diabetes.co.uk/insulin/insulin-sensitivity.html (1)

https://www.ncbi.nlm.nih.gov/books/NBK507839/ (2) 

Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action https://pubmed.ncbi.nlm.nih.gov/28704113/ (3)  Effects of resveratrol therapy on glucose metabolism, insulin resistance, inflammation, and renal function in the elderly patients with type 2 diabetes mellitus: A randomized controlled clinical trial protocol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371579/ (4)

https://academic.oup.com/jcem/article/91/12/4753/2656230?login=false (5)

 

References: The Role of Insulin Resistance in Nonalcoholic Fatty Liver Disease https://academic.oup.com/jcem/article/91/12/4753/2656230?login=false (1)

https://www.pnas.org/doi/10.1073/pnas.2007856117 (2) 

 

“In people with diabetes and pre-diabetes, increasing levels of HbA1c and age may be main factors related to impaired parasympathetic function” (1)

 

“Depression has been associated with both increased insulin resistance and reduced heart rate variability (HRV), the latter being an indicator of low parasympathetic drive” (2)

 

References: https://www.nature.com/articles/s41598-022-22675-2 (1) 

https://www.researchgate.net/publication/47383873_Lower_Parasympathetic_Drive_Insulin_Resistance_and_Depression (2)