We know gout is among the many comorbidities that increase the risk of cardiovascular disease (CVD). In 2018, the cardiovascular safety of febuxostat and allopurinol in patients with gout and cardiovascular morbidities (CARES) trial concluded that febuxostat was non-inferior to allopurinol. BUT, two of the secondary endpoints were very concerning. Febuxostat was inferior to allopurinol in terms of cardiovascular death and all-cause mortality. Many clinicians were left wondering whether febuxostat was cardiotoxic …. or conversely, perhaps allopurinol was cardioprotective. Will another cardiovascular outcome trial provide greater clarity to guide clinical practice?
Guest Authors: Sophia Dietrich, PharmD and Michael W. Nagy, PharmD, BCACP
Guest Panelist: Dawn Fuke, PharmD, BCPS
Music by Good Talk
Age is Just a Number: Discontinue Statins with Care
A Cause for a PAUSE: Evaluating a Standardized Perioperative DOAC Management Protocol
Who CARES? Getting to the Heart of Allopurinol and Febuxostat CV Outcomes
Up in Flames: Antiplatelet Therapy in Patients with Stable Ischemic Heart Disease Receiving Anticoagulation for A-fib
Is Dapagliflozin aDAPtAble to Treating HFrEF in Patients Without Diabetes?
Are Older Adults with Heart Failure Self-Care Aware?
Secondary Stroke Prevention in A-Fib: Do DOACs PROSPER in High-Risk Patients?
Under Pressure: Does Directly Observing Medication Administration Lower Blood Pressure?
Will Oral Semaglutide PIONEER the Way to Lower Cardiovascular Risk?
Using CRP in COPD to Guide Treatment Decisions During Exacerbations
Addressing the Adherence Problem: Do Med Sync Programs Really Work?
The Importance of a Healthy Mind in Patients with an Unhealthy Heart
Addressing the Concerns and Needs of Transgender Persons
The Power of Pharmacist-to-Pharmacist Handoffs During Transitions of Care
Improving Access to Naloxone - Yes, Pharmacists (Nar)CAN!
Making the GRADE: It’s time to AGREE on better CPGs
If Your Heart’s Not into It, Do You Really Need to Take Your Meds?
Should We Hold Our Breath for Vitamin D in COPD?
Breaking Up is Hard to Do: Are E-Cigarettes the Solution Tobacco Cessation?
Need a VITALity Boost? Rethink Vitamin D and Fish Oil Supplements
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