We know gout is among the many comorbidities that increase the risk of cardiovascular disease (CVD). In 2018, the cardiovascular safety of febuxostat and allopurinol in patients with gout and cardiovascular morbidities (CARES) trial concluded that febuxostat was non-inferior to allopurinol. BUT, two of the secondary endpoints were very concerning. Febuxostat was inferior to allopurinol in terms of cardiovascular death and all-cause mortality. Many clinicians were left wondering whether febuxostat was cardiotoxic …. or conversely, perhaps allopurinol was cardioprotective. Will another cardiovascular outcome trial provide greater clarity to guide clinical practice?
Guest Authors: Sophia Dietrich, PharmD and Michael W. Nagy, PharmD, BCACP
Guest Panelist: Dawn Fuke, PharmD, BCPS
Music by Good Talk
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Azithromycin to Prevent Asthma Exacerbations: What AMAZES Us and What Doesn’t
Painstaking Efforts to Improve Opioid Stewardship
Painting a New CANVAS for SGLT-2 Inhibitors?
Validating HERDOO2 - When is it Safe to Stop Therapy After an Unprovoked VTE?
Testing the Limits on Blood Glucose Monitoring: Can We Safely Cut Back?
Are Statins ALL THAT for Primary Prevention in Older Adults? A Second Look at ALLHAT-LLT
Wrapping up Knee Pain: Cabbage Leaf Wraps for Osteoarthritis of the Knee
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Peeling Back the Layers on Coated Aspirin
Antithrombotic Therapy Following Stent Placement in Patients with A-Fib: Should DOACs Be Preferred?
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Think Before You Make a RAS Decision: Evaluating the Use of RAS Blockers in Patients with Diabetes
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Is there a Role for Fixed-Ratio Injectable Combinations in Type 2 Diabetes?
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