Many studies have linked proton pump inhibitor (PPI) use to several adverse effects including Clostridium difficile-associated diarrhea, community-acquired pneumonia, bone fractures, and nutritional deficiencies. Other reports have linked PPI use with chronic kidney disease, cognitive decline, myocardial infarction (MI), stroke, and even death. Many patients take PPIs chronically and may be concerned about the risk of these side effects. This poses a challenge for healthcare providers as safety data has been primarily based on retrospective and observational studies. A recently pre-planned analysis using data from the prospective COMPASS study sheds some reassuring light.
Guest Authors: Hindu Rao, PharmD and Jelena Lewis, PharmD, BCACP, APh
Music by Good Talk
An Incli-ng of Benefit? Efficacy and Safety of Inclisiran for Elevated LDL
Will Riva Be Defeated By It’s (Long-Standing) Nemesis, Apixa?
Should Penicillin Allergy Skin Testing be a Thing of the PAST?
Is the Grass Really Greener? Cognitive Function After Discontinuation of Cannabis
A CLEAN Sweep: Getting Rid of the Medication Cost Barrier
Should Bedtime be Med-Time for Hypertension?
Let’s COLCOT to the Chase: Colchicine for Secondary Prevention of CV Events
Don’t Let Numbers Fool You: Levothyroxine Isn’t a Cure-all
Age is Just a Number: Discontinue Statins with Care
A Cause for a PAUSE: Evaluating a Standardized Perioperative DOAC Management Protocol
Who CARES? Getting to the Heart of Allopurinol and Febuxostat CV Outcomes
Up in Flames: Antiplatelet Therapy in Patients with Stable Ischemic Heart Disease Receiving Anticoagulation for A-fib
Is Dapagliflozin aDAPtAble to Treating HFrEF in Patients Without Diabetes?
Are Older Adults with Heart Failure Self-Care Aware?
Secondary Stroke Prevention in A-Fib: Do DOACs PROSPER in High-Risk Patients?
Under Pressure: Does Directly Observing Medication Administration Lower Blood Pressure?
Will Oral Semaglutide PIONEER the Way to Lower Cardiovascular Risk?
Using CRP in COPD to Guide Treatment Decisions During Exacerbations
Addressing the Adherence Problem: Do Med Sync Programs Really Work?
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