The Functional Breeding Podcast
Science:Life Sciences
Elinor Karlsson, Ph.D., is the director of the Vetebrate Genomics Group at the Broad Institute of MIT and Harvard and (incidentally) my boss. She has a deep knowledge about both population genetics and what we call "complex trait genomics," or the genetics of hard to pin down things like risk of developing cancer or a behavior problem. Elinor talked with me about a recent paper that looked for genetic variants associated with diseases in a large number of dogs from many breeds and mixes. She discusses what this paper found and some ways to intepret those findings. The paper is Donner, Jonas, et al. "Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs." PLoS genetics 14.4 (2018): e1007361. https://journals.plos.org/plosgenetics/article?rev=2&id=10.1371/journal.pgen.1007361.
Elinor also discusses a paper about genetic testing that she published recently, and that paper is Moses, Lisa, Steve Niemi, and Elinor Karlsson. "Pet genomics medicine runs wild." (2018): 470-472 https://www.nature.com/articles/d41586-018-05771-0.
Find this episode's transcript here.
Gina Bryson and Drs O'Neill and Packer: The Doodle Dilemma
What is the coefficient of inbreeding (COI) and why does it matter?
REPLAY: Jane Lindquist: Puppy Culture
Mary Peaslee, MD, MPH: Breeding for Population Health
Jessica Hekman, DVM, PhD, on "Lifetime Prevalence of Owner-Reported Medical Conditions"
What's up with FDC and the podcast
Dan O'Neill, MVB, PhD, FRCVS: Disorder Testing
Dan O'Neill, MVB, PhD, FRCVS: VetCompass and Inherited Disease
Danika Bannasch, DVM, PhD: The Dalmatian Outcross Project
Danika Bannasch, DVM, PhD: Chondrodystrophy
Lisa Gunter, PhD, CBCC-KA: Shelter Dog Welfare
Breeding for Companion Personalities: Carolyn Kelly, RN and Erica Pytlovany, KPA CTP
Claire Wade, PhD and Sophie Liu, DVM: The Doberman Genetic Diversity Paper
Lisa Wagner: Breeding Frenchies for Health
Sarah Stremming, CDBC: The Dog Sourcing Crisis
Jessica Hekman, DVM, PhD: State of the Functional Dog Collaborative
Laura Sharkey, PhD and Carolyn Kelly, RN: We All Have the Same Goals
Ji Khalsa, MS: Guardian Homes
Alison Skipper, PhD: the history of breed registries
Sarah Stremming, CDBC: Fear Periods
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