PECARN 1: Diabetic Ketoacidosis and Cerebral Edema

Hosted by Dr. Derek Monette (ALiEM Deputy Editor in Chief), this podcast discusses the hot-off-the-press New England Journal of Medicine publication on diabetic ketoacidosis (DKA), fluid resuscitation, and cerebral edema. Authors Dr. Nathan Kuppermann and Dr. Nicole Glaser explain the importance of their groundbreaking RCT and challenge the theoretical association between IV fluids and the development of cerebral edema during pediatric DKA treatment. Kuppermann N, Ghetti S, Schunk JE, et al; PECARN DKA FLUID Study Group. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. N Engl J Med. 2018 Jun 14;378(24):2275-2287. https://www.ncbi.nlm.nih.gov/pubmed/29897851