The BSH Guidelines Official Podcast
Health & Fitness:Medicine
CNS lymphoma (CNSL) is associated with inferior outcomes, which may be attributed to several factors: poor CNS penetrance of chemotherapeutics, including RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone),1 impaired neurocognitive function and patient performance status (PS) contributing to increased treatment toxicity,2, 3 and recurrent genetic aberrations conferring treatment resistance.4-6 The rarity and heterogeneity of SCNSL also limits the evidence base for treatment recommendations, with poor outcomes potentially attributable at least in part to lack of optimised treatment protocols.
This good practice paper focuses on diffuse large B-cell lymphoma (DLBCL), the most common SCNSL subtype. It covers diagnostic and therapeutic aspects of care for the three SCNSL scenarios and multiply relapsed SCNSL. Treatment recommendations are framed by patient fitness and treatment intent.
Guidelines on the diagnosis, investigation and initial treatment of myeloma
Guideline for diagnosis and management of hairy cell leukaemia (HCL) and hairy cell variant (HCL-V)
Guideline Frontline Management of Post Transplantation Lymphoproliferative Disorder in Adult Solid Organ Recipient Patients
Guideline The use of prophylactic factor replacement for children and adults with Haemophilia A and B
Guideline on the investigation and management of follicular lymphoma
Guideline on Laboratory aspects of assays used in haemostasis and thrombosis
Good Practice Paper: The prevention of central nervous system relapsed in diffuse large B- cell lymphoma
Guideline on the diagnosis and management of chronic myeloid leukaemia
Guidelines on the use of irradiated blood components
Guideline for the management of mantle cell lymphoma
UK guidelines on the management of iron deficiency in pregnancy
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