SLU-PP-332, 5-Amino-1MQ, and the Truth About Midlife Muscle & Fat
Hey friends, welcome back to Midlife Mayhem! I’ve just returned from a whirlwind trip through England and Greece—a mix of family remembrance, laughter, tears, chaos, and joy. I’m running on jet lag fumes, but I wanted to sit down and share something important with you today: two breakthrough compounds that could be absolute game-changers for midlife body composition—SLU-PP-332 and 5-Amino-1MQ.
👉 SLU-PP-332 is now available at www.slu332.com
👉 5-Amino-1MQ is available at www.5amino.com
👉 You can also buy both together at a discounted bundle price on either site.
And don’t forget—my Mastering Midlife program kicks off September 21 – November 1. Learn more and sign up at www.midlifemonth.com.
SLU-PP-332 – The "Exercise Mimicker"SLU-PP-332 attaches to a receptor on muscle cells and nudges them to burn fat for fuel.
By pushing muscles toward fat oxidation, it increases endurance, mimics the benefits of cardio, and protects muscle mass during calorie restriction.
This is why it’s often nicknamed an “exercise mimicker.”
In animal studies, it improved fat burning, increased endurance, and prevented muscle loss in calorie-restricted conditions.
Caveat: High doses over time may encourage fast-twitch fibers (the power fibers we lose with age) to behave more like slow-twitch endurance fibers. The solution? Always pair SLU-PP-332 with resistance training.
5-Amino-1MQ is a small molecule inhibitor that blocks the enzyme NNMT.
Why that matters: NNMT rises with age and acts like a metabolic brake, making fat cells better at storing fat and slowing NAD+ recycling.
By inhibiting NNMT, 5-Amino-1MQ:
Keeps NAD+ levels higher → better mitochondrial health and energy.
Reduces fat cell size and fat storage.
Lowers inflammation.
Helps preserve muscle through improved cellular energy.
I’ve been taking it for three years with consistent results—including not gaining weight on trips where, historically, I would have put on 3–5 lbs (despite extra eating, less routine, and long-haul flights).
SLU-PP-332 → tells muscles to burn fat as fuel and boosts endurance.
5-Amino-1MQ → prevents fat cells from storing more fat and supports cellular energy.
Different mechanisms, same goal: preserve muscle, burn more fat, and fight midlife metabolic slowdown.
You don’t have to take them together, but combined they offer a unique, complementary strategy.
Midlife frustrations—slower fat loss, muscle loss, stubborn belly fat, fatigue—are exactly what these compounds address.
Unlike GLP-1 weight-loss medications, these compounds don’t rely on suppressing appetite (which often leads to muscle loss you may never regain in midlife).
Instead, they support muscle protection, energy, fat burning, and inflammation reduction—without making it hard to eat protein or train.
Even during my two-week Europe trip—with flights, disrupted routines, and plenty of restaurant meals—I came back the exact same weight I left.
In the past, I’d always gain several pounds of bloat and fat. Since using 5-Amino-1MQ, that hasn’t happened once in three years of testing it.
Next, I’m excited to test SLU-PP-332 specifically for endurance—since it’s shown to improve performance in longer-duration exercise.
This is my flagship 6-week program for anyone 40+ who wants to feel sharp, strong, and capable in midlife and beyond.
Format: Two live Zoom coaching calls per week, for three weeks → one week off to catch up → then another two weeks of coaching.
Dates: September 21 – November 1
Access: Full library of 70+ content pieces plus direct access to me throughout.
Cost: $529 (payment plan available).
Sign up: www.midlifemonth.com
Topics we’ll cover include:
Optimized nutrition and why every food in my plans serves a purpose.
Training splits, strength vs endurance, and smarter—not harder—midlife training.
Mitochondrial health, NAD+, mTOR vs AMPK.
Midlife fasting, keto, cardio sweet spots, and recovery.
Hormones: insulin, cortisol, estrogen, progesterone, testosterone.
Pain, perimenopause, andropause, HRT & TRT.
Peptides, biohacks, supplements, and blood work panels.
Bone health, skin health, and processed food dangers.
Midlife is not the beginning of decline—it’s the opportunity window. Addressing body composition, hormones, and energy in your 40s–60s sets you up for vitality into your 70s, 80s, and beyond.
Quick LinksSLU-PP-332 → www.slu332.com
5-Amino-1MQ → www.5amino.com
Mastering Midlife (Sept 21 – Nov 1) → www.midlifemonth.com
Email me anytime with questions: jo@theshrinkshop.com