There are so many reasons to give up in life, so much suffering, work and tasks to be done and so little time per week to accomplish all. Additionally as a believer you may experience persecution and trouble.
There are so many reasons to give up, but there is one reason not to give up. The great hope is bigger than any trouble we experience. It is not just a vague hope, rather it is confirmed by the victory that Jesus has already won. Whoever holds out to the end will be saved.