Testosterone therapy is exploding in popularity, especially among midlife women — but how you take testosterone dramatically affects how it works in your body.
In this episode, Joanne breaks down the three major delivery systems — transdermal creams, oral lozenges, and injections — and explains why some women are now being told they’re “poor absorbers” and switched to oral or injectable forms.
You’ll learn:
Why women may not respond to topical testosterone (and why “poor absorber” is often misdiagnosed)...
Testosterone therapy is exploding in popularity, especially among midlife women — but how you take testosterone dramatically affects how it works in your body.
In this episode, Joanne breaks down the three major delivery systems — transdermal creams, oral lozenges, and injections — and explains why some women are now being told they’re “poor absorbers” and switched to oral or injectable forms.
You’ll learn:
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Why women may not respond to topical testosterone (and why “poor absorber” is often misdiagnosed)
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How creams differ from orals in absorption, side effects, and DHT conversion
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Why oral lozenges feel strong quickly — and the real reason they spike DHT
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Why injections seem aggressive but actually deliver the smoothest hormonal profile
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Which delivery system works best depending on your goals, symptoms, and physiology
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How men differ in absorption and why some men do brilliantly on gels while others might as well bathe in them
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How dosing, metabolism, and estrogen/testosterone balance influence results
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How to talk to your provider about choosing the right method
This episode is a must-listen for any woman navigating midlife hormones — and for men who want to understand why their therapy may or may not be working.
💉 Delivery Systems Explained
Joanne breaks down:
1. Transdermal Creams
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Gentle, steady, least DHT-converting
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Great for subtle libido, mood, strength improvements
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Why absorption varies wildly between women
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When creams are not enough
2. Oral Lozenges
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Fast-acting, potent, and sharp
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More likely to spike DHT
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Why these are often a solution for “non-responders” — but come with caveats
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The classic “love it or hate it” delivery method
3. Injections
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The smoothest and most predictable system
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Lowest DHT spikes compared to oral
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Best for consistent energy, stable mood, and strong results
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Why smaller, more frequent microdoses are often ideal for women
🔥 Who This Episode Is For
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Women feeling under-dosed or inconsistent on testosterone cream
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Women newly prescribed oral testosterone and unsure what to expect
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Anyone concerned about androgenic symptoms like acne, hair shedding, or irritability
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Men frustrated with gels or creams
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Anyone navigating TRT/HRT and wanting real science without fear or fluff
👀 Want More Like This?
This episode is part of Joanne’s in-depth midlife education series. If you love detailed, physiology-first coaching — not surface-level soundbites — you’ll love what’s coming next.
🌐 Explore the New Website
My brand-new website is live (not fully finished, but go have a peek):
👉 www.joannelee.com
This is where all upcoming programs, courses, podcasts, and resources will live.
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