The Gary Null Show - 05.20.21

Western diet found to impair function of immune cells in the gut

Cleveland Clinic, May 18, 2021

According to new study results, a team of researchers led by Cleveland Clinic's Thaddeus Stappenbeck, M.D., Ph.D., have found that a diet high in fat and sugar is associated with impaired intestinal immune cell function in mice. The findings, published in Cell Host & Microbe, provide novel insights into pathways linking obesity and disease-driving gut inflammation, and have implications for developing targets to treat inflammatory bowel diseases (IBD) in patients.

Using data from more than 900 patients, the researchers found that elevated body mass index is associated with abnormal Paneth cells among patients with Crohn's disease and non-IBD patients.

Paneth cells are a type of anti-inflammatory immune cell found in the intestines that helps to protect against microbial imbalances and infectious pathogens. Dysfunction of these cells is driven by a combination of genetic mutations and environmental factors. Dr. Stappenbeck and others have previously linked Paneth cell dysfunction to gut changes indicative of IBD in preclinical models and a subset of Crohn's disease patients from multiple cohorts around the world.

"With this understanding, we set out to investigate whether diet-induced obesity--specifically caused by a diet high in fat and sugar, or a 'western diet'--is one of the environmental factors that can lead to impaired Paneth cell function," said Dr. Stappenbeck, chair of Lerner Research Institute's Department of Inflammation & Immunity.

The researchers compared the effects of a western diet versus a standard diet. The team's western diet contained about 40 percent fat and an elevated level of simple carbohydrates, which better resembles the diet of an average U.S. adult than regimens prescribed in other preclinical studies.

After eight weeks, the group that ate the western diet had more abnormal Paneth cells than the group that ate a standard diet. In the western diet group, other changes become apparent two months after the Paneth cell defects, including increased gut permeability, where bacteria and toxins can enter the gut and which is well-linked with chronic inflammation. Notably, however, switching to a standard diet from the western diet completely reversed the Paneth cell dysfunction.

"When we started to look into large-scale datasets for the specific mechanisms that might connect the high-fat, high-sugar diet with the Paneth cell dysfunction, a secondary bile acid called deoxycholic acid caught our attention," said Dr. Stappenbeck. 

Deoxycholic acid is a metabolic byproduct of intestinal bacteria. Researchers found that consuming a western diet increased the bile acid in a region of the intestines called the ileum and, as a result, increased the expression of two downstream molecules, farnesoid X receptor (FXR) and type I interferon (IFN).

"For the first time, we showed how coordinated elevation of FXR and type I IFN signals in multiple cell types contribute to Paneth cell defects in response to a diet high in fat and sugar. In previous research, stimulating FXR has shown to help treat other diseases, including fatty liver disease, so we are hopeful that with additional research we can interrogate how the combination of elevated FXR and IFN signals can be targeted to help treat diet-induced gut infections and chronic inflammation."

Dr. Stappenbeck also explained that while the team was interested to learn that changing the diet regimen reversed the pathological changes, more research would be needed to determine if these changes also occur in patients.

 

 

Count your blessings: Short gratitude intervention can increase academic motivation

Ritsumeikan University (Japan), May 17, 2021

 

Because of the ongoing pandemic, lifestyles have been subjected to drastic and dynamic changes, and many work- and study-related activities are now carried out online exclusively. This, among other complex factors, has made it difficult for some people to stay focused and motivated, and psychology researchers are trying to find effective and widely applicable solutions to address such problems.

In a recent study published in BMC Psychology, researchers from Ritsumeikan University and the National Institute of Information and Communications Technology (NICT), Japan, have explored a simple strategy to increase motivation in college students by nurturing a positive emotion: gratitude. Many studies have shown that even short "gratitude interventions," which are activities that increase an individual's awareness of feelings of gratitude, can have a lasting positive effect on that person's mood, satisfaction and well-being. However, based on previous studies, the available evidence on the effect of such interventions on academic motivation is inconclusive. This prompted the researchers to test the effects of a different type of gratitude intervention: daily gratitude journaling.

"Our main hypothesis was that engaging in an online gratitude journal by writing down up to five things one felt grateful for each day could make students be more aware of their academic opportunities—their 'blessings'—and help them re-evaluate their motives and goals, ultimately improving their motivation," explains Dr. Norberto Eiji Nawa from NICT, first author of the study. They recruited 84 participants, all Japanese college students, and divided them into a control group and an intervention group. Over the course of two weeks, students in both groups had to evaluate aspects of their daily life through online questionnaires each day, but only the intervention group had to keep the online daily gratitude journal. At the start of the intervention and after one and two weeks, and one and three months, the participants had to complete the Academic Motivation Scale (AMS), a tried-and-tested tool for measuring different aspects of academic motivation.

The results were promising; through statistical analyses, the researchers found that the gratitude intervention through daily journaling significantly increased the students' academic motivation. Most notably, this robust positive effect was not restricted only to the two-week period of the intervention, as the increased level of academic motivation was maintained even after three months. In addition, through an exploratory analysis, the researchers established that the enhancement in academic motivation was mostly driven by a decrease in "amotivation scores." Amotivation, in this context, refers to the state in which a person perceives that their own actions are irrelevant to the resulting outcomes, leading to feelings of helplessness and incompetence.

Academic motivation can be one of the primary determinants of both academic achievements and satisfaction with school life, and developing widely applicable intervention strategies is critical to foster student growth. "Online interventions have the advantage of being more accessible, scalable and affordable to large portions of the population. Gathering solid evidence to support their deployment will be essential to unleash their true potential in the future," concludes Professor Noriko Yamagishi from Ritsumeikan University. It appears that the positive impact of gratitude interventions extends well beyond the already documented effects on individual well-being.

This study was partly supported by a research grant from the Ritsumeikan Inamori Philosophy Research Center. This Center aims to promote multidisciplinary research on the management philosophy advocated by Dr. Kazuo Inamori, a prominent Japanese entrepreneur and renowned philanthropist. With this major goal in mind, Professor Yamagishi, alongside Dr. Nawa, have been working on the scientific elucidation of the emotions of "altruism" and "gratitude" from the perspective of cognitive psychology and neuroscience. This particular study was conducted as part of this more overarching research. Until the day these human emotions become clearer, we can safely give this piece of advice: remember to count your blessings.

 

How Quickly Do We Become Unfit?

 

Anglia Ruskin University, May 14, 2021

Getting in shape isn’t easy. But after all that hard work, how long do we actually maintain it? Turns out that even the great effort we put into training, taking a bit of time off can mean that we become “unfit” much faster than it took us to actually get in shape.

To understand how the body becomes “unfit”, we first need to understand how we become fit. The key to becoming fitter – whether that’s improving cardiovascular fitness or muscular strength – is to exceed “habitual load”. This means doing more than our body is used to. The stress that this has on our body makes us adapt and become more tolerant, leading to higher fitness levels.

The time it takes to get fit depends on a number of factors, including fitness levels, age, how hard you work, and even environment. But some studies do indicate that even just six sessions of interval trainingcan lead to increases in maximal oxygen uptake (V02 max) – a measure of overall fitness — and improve how efficiently our body is able to fuel itself using the sugar stored in our cells during exercise.

For strength training, some gains in muscle force can be shown in as little as two weeks, but changes in muscle size won’t be seen until around 8-12 weeks.

Cardiovascular fitness

When we stop training, how quickly we lose fitness also depends on many factors – including the type of fitness we’re talking about (such as strength or cardiovascular fitness).

As an example, let’s look at a marathon runner, who is in peak athletic fitness and can run a marathon in two hours and 30 minutes. This person spends five to six days a week training, running a total of 90km. They’ve also spent the last 15 years developing this level of fitness.

Now let’s say they stopped training completely. Because the body no longer has the stresses of training forcing it to stay fit, the runner will start to lose fitness within a few weeks.

Cardiorespiratory fitness – indicated by a person’s V02 max (the amount of oxygen a person can use during exericse) – will decrease around 10% in the first four weeksafter a person stops training. This rate of decline continues, but at a slower rate over longer periods.

Intriguingly, though highly trained athletes (like our marathon runner) see a sharp decline in V02 max in the first four weeks, this decline eventually evens out, and they actually maintain a V02 higher than the average person’s. But for the average person, V02 max falls sharply, back to pre-training levels, in less than eight weeks.

 

The reason V02 max declines is due to reductions in blood and plasma volumes – which decrease by as much as 12% in the first four weeks after a person stops training. Plasma and blood volume decrease due to the lack of stress being put on our heart and muscles.

Plasma volume may even decrease by around 5% within the first 48 hours of stopping training. The effect of decreased blood and plasma volume leads to less blood being pumped around the body each heart beat. But these levels only drop to where we started – meaning we won’t get worse.

Of course, most of us aren’t marathon runners – but we’re also not immune to these effects. As soon as we stop exercising the body will start to lose these key cardiovascular adaptations at a very similar rate as highly trained athletes.

Strength training

When it comes to strength, evidence shows that in the average person, 12 weeks without training causes a significant decrease in the amount of weight we can lift. Thankfully, research shows that you maintain some of the strength you gained before you stopped training. What is intriguing is that despite the significant decrease in strength, there’s only a minimal decrease in the size of the muscle fibres.

The reason we lose muscle strength largely has to do with the fact that we’re no longer putting our muscles under stress. So when we’re no longer working our muscles hard, the muscles become “lazy”, leading the number of our muscle fibres to decrease, and fewer muscles being recruited during an activity – making us less able to lift the heavy loads we used to.

The number of muscle fibres used during exercise decreases by around 13% after just two weeks of no training – though this appears not to be accompanied by a decline in muscular force. This implies that the losses observed across the longer periods of detraining are a combination of both this initial decline in the number of muscle fibres we use, but also the slower decline in muscle mass.

For the average gym goer who lifts weights, they would experience a drop in the size of their muscles – over time finding it harder to lift heavy loads as they have less muscle fibres being recruited.

So even after all that effort to get fit, we start losing cardiovascular fitness and strength within 48 hours of stopping. But we don’t start to feel these effects for at least two to three weeks for cardiovascular fitness and around 6-10 weeks for strength. Rates of “de-training” are similar for men and women, and even for older athletes. But the fitter you are, the slower you’ll lose your gains.

 

Non-drug therapies as good as or better than drugs for treating depression in people with dementia

St Michael’s Hospital, University of Toronto, University of Calgary May 17, 2021

 

Doctors should consider more "social" prescribing of non-drug approaches for depression and loneliness, say researchers

Non-drug therapies, such as exercise, appear to be as, or more, effective than drugs for reducing symptoms of depression in people with dementia, suggests research published online in The BMJ.

The findings suggest that people with dementia will derive a clinically meaningful benefit from non-drug interventions, and the researchers say doctors should consider more "social" prescribing of non-drug approaches to treat symptoms of depression and loneliness.

Fifty million people worldwide have a diagnosis of dementia. About 16% of these people also have a diagnosed major depressive disorder, and 32% will experience symptoms of depression without a formal diagnosis.

Previous trials have shown that non-drug approaches, such as exercise, alleviate symptoms of depression in people with dementia, but it's not clear how effective they are compared with drugs to reduce symptoms of depression.

To address this uncertainty, researchers analysed the results of existing trials to compare the effectiveness of drug and non-drug interventions with usual care or any other intervention targeting symptoms of depression in people with dementia.

After screening 22,138 records, they focused on and reviewed 256 studies involving 28,483 people with dementia, with or without a diagnosed major depressive disorder.

Drug approaches alone were no more effective than usual care, but they found 10 interventions associated with a greater reduction in symptoms of depression compared with usual care.

These were cognitive stimulation, exercise, reminiscence therapy (a treatment to help people with dementia remember events, people and places from their lives), cognitive stimulation with a cholinesterase inhibitor (a drug used to treat dementia), massage and touch therapy, multidisciplinary care, psychotherapy combined with reminiscence therapy and environmental modification, occupational therapy, exercise combined with social interaction and cognitive stimulation, and animal therapy.

Three interventions -- massage and touch therapy, cognitive stimulation with a cholinesterase inhibitor, and cognitive stimulation combined with exercise and social interaction -- were found to be more effective than some drugs.

The authors acknowledge some study limitations, such as being unable to explore severity of depression symptoms or effects on different types of dementia. Nor did they look at the potential costs or harms of implementing drug and non-drug interventions.

However, notable strengths included the large number of articles reviewed and use of a recognised clinical scale for capturing symptoms of depression.

As such, they say in this systematic review, "non-drug approaches were associated with a meaningful reduction in symptoms of depression in people with dementia and without a diagnosis of a major depressive disorder.

And they add that everyone -- patients, caregivers, clinicians and policy makers -- have a role in translating these findings into practice

 

 

Omega-3 lowers childhood aggression in short term, Penn research shows

University of Pennsylvania, May 13, 2021

Incorporating omega-3, vitamins and mineral supplements into the diets of children with extreme aggression can reduce this problem behavior in the short term, especially its more impulsive, emotional form, according to University of Pennsylvania researchers who published their findings in the Journal of Child Psychology and Psychiatry.

Adrian Raine, the Richard Perry University Professor of Criminology, Psychology and Psychiatry, has spent his career looking at how the brain's biological functioning affects antisocial behavior. He focuses specifically on understanding these actions and learning how to modify them, whether with something benign like a child acting out or with something extreme, in the case of a homicidal killer.

"How do you change the brain to make people better?" he asked. "How can we improve brain functioning to improve behavior?"

These questions formed the foundation for work Raine had previously done with adolescents on the African island of Mauritius. In a randomized control trial, one group received omega-3 supplements for six months, the other didn't. Those taking the fish oil saw a reduction in aggressive and antisocial behavior.

"That was my starting point," he said. "I was really excited about the results we published there."

Mauritius, however, is a tropical climate and a different culture from the United States, so Raine, a Penn Integrates Knowledge Professor, decided to test a new version of the study in Philadelphia, to aim for more broadly applicable outcomes. He partnered with Therese Richmond, the Andrea B. Laporte Professor of Nursing and associate dean for research and innovation, and several other Penn faculty, including Rose Cheney of the Perelman School of Medicine and Jill Portnoy of the Criminology Department in the School of Arts & Sciences.

The Philadelphia randomized control study placed 290 11- and 12-year-olds with a history of violence into four groups: The first received omega-3 in the form of juice, as well as multivitamins and calcium for three months. For that same duration, a second group participated in cognitive behavioral therapy, or CBT, which included meeting weekly for an hour, with time split between the child, the parent and with both together.

"Sessions focused on the links between thoughts, feelings and behaviors and also practicing alternative actions the children could take to deal with difficult situations rather than to emotionally react to something," said Richmond, who supervised the clinical trial. "It's helping the child build a toolbox of ways to interact with others. For example, if I'm angry, how might I cope with anger other than physically striking out?"All participants got homework, too.

A third group in the study took the supplements and participated in CBT, and a fourth received resources and information targeted at reducing aggressive behavior. Blood samples at the experiment's start and conclusion measured omega-3 levels in each child.

"Immediately after three months of the nutritional intervention rich in omega-3s, we found a decrease in the children's reporting of their aggressive behavior," Richmond said. The team also followed up three and six months later.

At the first check-in, participants getting the combination of CBT and omega-3s reported less aggression than the control group and the therapy-only group. By the final check-in, however, any positive effects had dissipated. What remains unknown is whether continued use of omega-3s would lead to a long-term reduction in antisocial behavior.

There were other minor limitations to the research. For one, self-reporting completed by parents and children didn't line up. The 11- and 12-year-olds in the omega-3 and CBT-supplement groups noted fewer aggressive behaviors; their parents said such tendencies hadn't changed. Also, some participants dropped out before the study had finished.

Despite these challenges, Raine, Richmond and their colleagues said the findings provide some important insight.

"No matter what program you use, could adding omega-3s to your treatment help?" Raine asked. "This suggests it could."

And though the work answers some questions, it also creates new ones, which returns to a larger point regarding the mind-action connection: It's complicated.

"We can't oversimplify the complexity of antisocial behavior. There are many causes," Raine said. "It's not just the brain. Is it a piece of the jigsaw puzzle? I think it is."

 

 

Lockdown led to positive lifestyle changes in older people

University of Stirling (Scotland), May 17, 2021

The COVID-19 lockdown was a catalyst for many older people to embrace technology, reconnect with friends and build new relationships with neighbours, according to University of Stirling research.

Understanding the coping mechanisms adopted by some over 60s during the pandemic will play a key role in developing interventions to help tackle loneliness, isolation and wellbeing in the future.

The study, led by the Faculty of Health Sciences and Sport, surveyed 1,429 participants - 84 percent (1,198) of whom were over 60 - and found many had adapted to video conferencing technology to increase online contact with existing social networks, while others reconnected with previous networks. Participants reported that lockdown had led them to engage with neighbours and other members of their communities for the first time, while several said social distancing had brought an additional meaning to life, by highlighting what was important to them.

Published in the International Journal of Environmental Research and Public Health, the paper comes six months after the study - funded under the Scottish Government Chief Scientist Office's Rapid Research in COVID-19 programme - reported in its preliminary findings that social distancing had increased feelings of loneliness in older people.

Professor of Behavioural Medicine, Anna Whittaker, who led the study, said: "Our research found that the COVID-19 lockdown triggered feelings of loneliness in older people - with many experiencing less social contact and support. However, the study also highlighted positive outcomes, for example, lockdown encouraged some older people to embrace and engage with technology - such as Zoom, Whatsapp or FaceTime - to stay in touch with loved-ones or participate in exercise classes or religious groups. Those who engaged in such activity were able to prevent high levels of loneliness, therefore, helping older adults to increase their digital literacy and use of remote social interactions could be a really important tool for addressing loneliness.

"Participants also reported actively looking for new social contact while restrictions were in place - such as contacting friends who they had not spoken to in years and increasing interactions with neighbours and other members of their communities. Significantly, many of our participants reported that social distancing has actually led them to find new sources of satisfaction in life.

"Our study also highlighted that encouraging safe social contact through physical activity and engaging with people in the community may be an effective way to reduce loneliness, improve wellbeing, increase social activity, and improve social support."

The study - which involved a survey conducted between May and July 2020 - examined the impact of social distancing during the pandemic on loneliness, wellbeing and social activity, including social support, in Scottish older adults.

Participants were asked about the strategies they adopted to increase social interaction during this time and reported that the way they interacted with their friends and family, faith, chosen group activities and, to a lesser extent, their employer and colleagues, had changed. More than 300 participants mentioned 'Zoom' - the video conferencing tool - in their answers.

More than 150 participants reported that their religious gatherings had moved online - replacing face-to-face gatherings - while 91 said that social gatherings with family and friends had changed in favour of online 'games nights'. New activities included bingo and quiz nights, while other activities moved online - such as bridge nights, book clubs, choir rehearsals, and dance and exercise classes.

The role of community - particularly neighbours - was mentioned by more than 300 participants and some reported the common experience of getting to know previously unknown neighbours and increase interaction with others in the community at local shops or parks. A pleasant Scottish summer also supported such interactions, several said.

At least 100 people said social interactions were linked to their physical activities - such as time spent outdoors while walking for exercise, walking the dogs or active commuting.

Professor Whittaker added: "Our research underlines the importance of addressing loneliness and social support in older adults - but particularly during situations where risk of isolation is high. Although specific to the pandemic, this study has wider implications of helping us to understand the impact of social distancing and social isolation on older people.

"The findings may be applicable in the future - both in and outwith pandemic situations. In Scotland, the recommendations for improvement may be through encouraging older adults to get to know their neighbours better, getting involved with local buddying systems and community initiatives, including via digital means, and engaging in physical activity, such as daily walks in the community."

Brian Sloan, Chief Executive of Age Scotland, said: "While it may prove difficult to consider any aspect of the pandemic positive as such, it is important and worthwhile to reflect on what it has taught us, both about ourselves and society and about the necessary tools to tackle Scotland's increased levels of loneliness and isolation.

"For example, we've seen first-hand how important the community response has been in terms of supporting older people throughout lockdown and it has been inspiring to witness how people across the country stepped in and stepped forward to help those in need around them. Even as restrictions ease, we hope to see this sense of community spirit continue. 

"The ongoing impact of COVID-19 has also demonstrated just how important increased digital inclusion is and how easily those without access to technology can feel out of the loop. It's reassuring to see so many older people reporting that they have been able to embrace and engage with technology to stay connected and active. 

"However, it's equally important to ensure those who are unable or do not wish to use the internet have alternative ways to stay connected to their communities and support networks.

"As we take steps towards recovery together, it is vital that no one is left behind and those most impacted are supported to play a full part in society again. 

"We know we will be living with the ongoing effects of lockdown loneliness for a long time to come, and this research will be incredibly valuable when considering how best to tackle loneliness and isolation and to improve the wellbeing of older people going forward."

 

 

Signs of Vitamin B12 Deficiency

World Health Net,  May 1, 2021

Modern nutritional research offers much more information about which nutrients are required for optimal health than in years past. The general opinion of most health care providers has been that patients should eat a balanced diet in order to make sure their nutritional needs are being met. Until the past few decades this was good advice, but the nutrients contained in most foods sold in grocery stores has been depleted, due to the way they were grown and processed. This means the nutrients most important to the proper functioning of the human body are best ingested through supplementation. Those who have a deficiency of vitamin B12 may be experiencing some serious health problems that they are not even aware of.

Food Sources of Vitamin B12
Food products that come from animals are the only sources of the vitamin, so someone who follows a vegetarian or vegan diet would most likely need to supplement B12. It is also good to supplement if one has a diet that restricts the consumption of meat, dairy, eggs because of the relatively high levels of cholesterol and fat. 

Health Problems Caused by a Vitamin B12 Deficiency
Some of these health issues are easily mistaken as symptoms of other diseases, such as diabetes. Others may be confused with common aging problems.

• Weakness
• Fatigue
• Tingling and/or numbness in the extremeties
• Memory loss and cognitive difficulties
• Difficulty in walking, because of staggering or balance problems

Health care providers may not be able to identify these problems as a deficiency of Vitamin B12, so a blood test may be needed, in order to reach a correct diagnosis. There are a few other less common symptoms that indicate a deficiency of the vitamin.

• Paranoia and hallucinations
• Anemia
• Jaundiced skin
• An inflamed and swollen tongue

Many people are not very well educated about their nutritional needs and the problems they may experience from various deficiencies. Most people have too much stress in their lives and struggle to find enough time in the day to get everything done. People often naturally think whatever fatigue or weakness they feel is the result of not enough time and rest, but symptoms could well be due to a Vitamin B12 deficiency. 

Although seniors are most at risk for nutritional deficiencies due to dietary restrictions, a depressed appetite and medications, younger women also experience anemia due to monthly menstruation. The average person is often surprised how much better they feel once they begin a regime of Vitamin B12 supplementation. It is important to note that not all B12 supplements are the same, so if adding the vitamin to a diet it would be wise to research all the options available. One common B12 supplement actually contains arsenic and should be avoided.

Since the best source of B12 is found in foods, eating more meat, eggs, dairy and especially poultry is a good choice. Poultry is relatively low in fat and cholesterol, so it is safer for those who are at risk for heart disease.