The International Symposium on Hodgkin Lymphoma (ISHL) 2021 Hodgkin Lymphoma (HL) update gathered an international panel to discuss the most recent developments in HL, and provided a comprehensive update on current and emerging concepts. In this podcast, we spoke to Sven Borchmann, MD, of the University Hospital Cologne, Cologne, Germany, Paul Jan Bröckelmann, MD of the University Hospital of Cologne, Cologne, Germany, and Alison Moskowitz, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, as they outline the latest thinking in HL, touching on the use of biomarkers in HL, first-line approaches as well as updates in relapsed/refractory disease.