S1E07 - Proteostasis & Macroautophagy

Season 1: The Science of Aging | Episode 7: Proteostasis & Macroautophagy

In this riveting episode of The Deep Dive, we explore the intricate world of cellular processes that govern our biological aging. Join us as we delve into the microscopic realm where cells manage their own internal environment through sophisticated quality control mechanisms like proteostasis and macroautophagy. Discover the significance of molecular chaperones, ubiquitin proteasome systems, and the autophagy lysosome pathways in maintaining cellular health.

Our discussion highlights how these essential processes influence aging and play a critical role in preventing age-related diseases. We navigate through the concept of how the cell's ability to manage waste affects not only its longevity but also its overall function and vitality. Learn how enhanced cellular maintenance systems can lead to a longer, healthier life, contrasting the conditions of severe neurodegenerative diseases with the vitality observed in centenarians.

This episode offers a comprehensive understanding of how maintaining effective cellular cleaning is crucial for healthy aging. Tune in to uncover the profound biological insights that hold transformative potential for future anti-aging strategies and therapies.